Hashimoto
Thyroiditis
(Chronic Lymphocytic Thyroiditis)
Common sites:
Gross features:
- diffusely enlarged
thyroid
- sometimes
localized enlargement
- intact capsule
- cut surface pale,
yellow-tan, firm, somewhat nodular
Histologic features:
- extensive mononuclear
infiltrate
- lymphocytes, plasma
cells
- well-developed
germinal centres
- atrophic follicles lined
in many areas by Hurthle cells
- abundant, eosinophilic,
granular cytoplasm
- increased or
abundant interstitial connective tissue
- fibrous variant has
severe follicular atrophy and dense "keloid-like" fibrosis
(broad bands of acellular collagen)
- fibrosis does not
extend beyond the capsule of the gland
- cytology:
- Hurthle cells
- Heterogenous population
of mononuclear lymphocytes
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features: