Hurthle Cells

 

Epidemiology:

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Common sites:

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Gross features:

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Histologic features:

    • abundant granular eosinophilic cytoplasm
      • may have clear cell change
    • variation in nuclear size
    • prominent nucleoli often (more indicative of benign lesion)
    • mild nuclear atypia:
      • overlapping
      • pleomorphism
      • mild features of papillary carcinoma

 

Immunophenotype:

Marker:

Sensitivity:

Specificity:

“sticky” cells – may have nonspecific staining, ex. calcitonin 

 

 

 

Molecular features:

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Other features:

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References:

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