Insular Carcinoma

(Poorly Differentiated Carcinoma)

Epidemiology:

Common sites:

Gross features:

• large
• gray-white
• infiltrative
• extensive necrosis

Histologic features:

• small nests of cells with a neuroendocrine growth pattern
• necrosis prominent
• mitoses prominent
• vascular invasion prominent

Immunophenotype:

Marker:	Sensitivity:	Specificity:
Thyroglobulin
Calcitonin (neg)

Molecular features:

Other features: