Endometrial Intraepithelial Carcinoma (EIC)

Epidemiology and Etiology:

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Common sites:

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Gross features:

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Histologic features:

· Background endometrium:

· Atrophic maybe

· Weakly proliferative maybe

· Polypoid maybe

· Epithelium containing 1 to a few layers of large cells

· Amphophilic to basophilic cytoplasm

· Large, often bizarre nuclei

· Large eosinophilic nucleoli

· No hyperplastic architecture

Immunophenotype:

Marker:	Sensitivity:	Specificity:
P53 (strong diffuse)		Usually weak and patchy in hyperplasia and endometrioid CA

Molecular features:

·

Other features:

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References:

· Silverberg SG, DeLellis RA, Frable WJ, LiVolsi VA, Wick MR. Silverberg's Principles and Practice of Surgical Pathology and Cytopathology: 2-Volume Set. 4th ed. Churchill Livingstone; 2005.