Churg-Strauss
Syndrome
Epidemiology:
Common sites:
- lung
- heart
- spleen
- peripheral nerves
- skin
Gross features:
Histologic features:
- necrotizing vasculitis accompanied by granulomas
with eosinophilic necrosis
- intravascular
and extravascular granulomas
- striking
infiltration of vessels and perivascular
tissues by eosinophils
- may have similar
vascular lesions to PAN or microscopic polyangiitis
- early prevasculitic phase:
- tissue
infiltration by eosinophils
- no overt vasculitis
Immunophenotype:
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Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- p-ANCAs in 50%
- strong association
to:
- allergic
rhinitis
- asthma
- eosinophilia
- coronary arteritis
and myocarditis are principal cause of
morbidity and mortality
References: