Kawasaki Disease

Epidemiology and Etiology:

· Uncertain etiology

· Young children usually

Common sites:

· Cervical lymph nodes

Gross features:

· Conjunctival congestion

· Oral mucous membrane lesions

· Polymorphous exanthema

· Cervical lymphadenopathy

Histologic features:

· Lymph node:

· Necrotizing lesions

· Fibrin

· Karyorrhectic debris

· Neutrophils

· Fibrin thrombi in small vessels usually prominent

· Also seen in Rickettsial infection and thrombocytopenic purpura

· Arteritis with fibrinous necrosis maybe

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

·

Other features:

· Acute febrile illness

· 5 of 6 clinical criteria must be present:

· Fever

· Congestion of the conjunctiva

· Oral mucous membrane lesions

· Distal extremity lesions

· Polymorphous exanthema

· Acute cervical adenopathy

· May be life threatening when coronary arteritis is present

· Rare cases of malignant lymphoma following Kawasaki disease

References:

· Silverberg SG, DeLellis RA, Frable WJ, LiVolsi VA, Wick MR. Silverberg's Principles and Practice of Surgical Pathology and Cytopathology: 2-Volume Set. 4th ed. Churchill Livingstone; 2005.