Cystic Medial Degeneration

Epidemiology and Etiology:

· Marfan’s

· Hypertension

· Idiopathic aortic root dilation

Common sites:

· Aortic root

Gross features:

·

Histologic features:

· Elastic fibre loss in the media

· Proteoglycan deposition in these sites

· Loss of smooth muscle cells

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

·

Other features:

·

References:

· Silverberg SG, DeLellis RA, Frable WJ, LiVolsi VA, Wick MR. Silverberg's Principles and Practice of Surgical Pathology and Cytopathology: 2-Volume Set. 4th ed. Churchill Livingstone; 2005.