Squamous Cell
Carcinoma of the Vulva
Epidemiology:
- Divided into 2
groups:
- HPV-associated
- Non-differentiated
VIN
- Multicentric
- Younger women
- Non-HPV
associated
- Arising from
lichen sclerosis, lichen simplex chronicus, differentiated
VIN (simplex)
- Solitary
- Older women
Common sites:
Gross features:
Histologic features:
- HPV-associated:
- “intraepithelial-like”
pattern – similar to HPV-associated VIN
- non-HPV
associated:
- grading is based
on percentage of poorly-differentiated tumour:
- <5% - grade 1
- 5-50% - grade 2
- >50% - grade
3
- other important
prognostic information:
- lymphovascular invasion
- perineural invasion
- thickness
- depth
Immunophenotype:
Marker:
|
Sensitivity:
|
Specificity:
|
|
|
|
Molecular features:
Other features: