Vulvar
Intraepithelial Neoplasia (VIN)
Epidemiology:
- in young women:
- HPV often
associated
- Multiple often
- progression to
carcinoma uncommon
- in older women:
- HPV not
associated
- solitary often
- higher risk for
progression to carcinoma
Common sites:
Gross features:
- white or pigmented
plaque
- frequently multicentric
Histologic features:
- HPV-associated
type:
- nuclear atypia
- nuclear crowding
- loss of polarity
- increased
mitoses
- lack of surface
differentiation
- Differentiated
type (VIN Simplex):
- Basal cell atypia
- Maturation
- Hyperkeratosis
Immunophenotype:
Marker:
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Sensitivity:
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Specificity:
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Molecular features:
Other features:
- 10-30% associated
with another primary squamous neoplasm in the
vagina or cervix