Cervical Squamous Cell Carcinoma

Common sites:

Gross features:

• fungating, ulcerating, and infiltrative patterns

Histologic features:

• foci of stromal invasion:
• irregular contour, in contrast with surrounding epithelium bound by smooth contour of basement membrane
• scalloping of the dermal-epidermal interface at site of invasion
• better differentiated appearance with abundant cytoplasm and prominent nucleoli
• lymphoplasmocytic infiltrate and/or desmoplastic response in surrounding stroma
• occasional small focus of keratinization
• keratinization:
• squamous pearls
• individual cells with markedly eosinophilic dense cytoplasm
• intercellular bridges
• differentiation:
• well-differentiated – above features are seen readily
• mod-differentiated – above features seen easily but not extensively
• poorly-differentiated – above features are focally seen

Immunophenotype:

Marker:

Sensitivity:

Specificity:

Molecular features:

Other features:

• common metastatic sites:
• local – peritoneum, bladder, ureters, rectum vagina
• distant – liver, lung, bone marrow