Reactive Changes in Squamous Epithelium

 

Epidemiology:

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Common sites:

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Gross features:

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Histologic features:

    • intercellular edema (spongiosis)
    • intraepithelial neutrophils
    • evenly-spaced nuclei
      • distinct cell borders
    • mild-to-moderate nuclear enlargement
      • minimal nuclear pleomorphism 
      • prominent nucleoli
      • binucleation may be seen
    • superficial maturation
      • incomplete maturation may be present
      • superficial epithelial cells do not show nuclear enlargement / pleomorphism

 

Immunophenotype:

Marker:

Sensitivity:

Specificity:

 

 

 

 

Molecular features:

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Other features:

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