Acute Viral Hepatitis
Gross features:
- Enlarged,
erythematous liver
- Greenish
if cholestatic
Histologic
features:
- Hepatocyte damage:
- Ballooning
degeneration
- Necrosis
- Apoptosis
- Hepatocyte proliferation
- Canalicular bile plugs
- Inflammatory
cells:
- Periportal inflammatory
infiltrate, predominantly mononuclear
- Macrophage
aggregates in sites of hepatocyte loss
- Kupffer cell hypertrophy and
hyperplasia
- Phagocytosed cellular debris and lipofuscin pigmentin Kupffer cells
- Mononuclear
cells in sinusoids
- Bridging
necrosis if severe