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| One major area of investigation is the embryonic and postnatal development of the mammary gland. Here we focus on the role of the homeodomaimn factor, Alx4, as well as the Wnt- and Hedgehog-signalling pathways. In the case of the Wnt pathway, the role of the downstream mediator, LEF-1, is being studied at the molecular level as well as through the use of genetic models, specifically transgenic mice. Likewise, the role of the Hedgehog-signalling pathway in both the embryonic and postnatal mammary gland is being studied. The activities of these pathways during the malignant transformation of the mammary gland (i.e. breast cancer) is also under investigation. |
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Current Lab Personnel:
Dr. Hong Chang Malcom Harvey Nadia Okolowsky Aaliya Tamachi |
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Paul A. Hamel
Professor, Faculty of Medicine & Director, Health Studies, University College University of Toronto |
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