TONY PANZARELLA
E-mail: tony.panzarella@utoronto.ca
§ A highly motivated, results-oriented
biostatistician, with over thirty years of proven success in a clinical cancer
research setting.
§ Co-author of over one hundred and
forty peer-reviewed journal articles
§ Co-investigator/collaborator on
numerous grants (e.g. NIH, CIHR, CCSRI).
§ Versatile team player with
excellent communication skills
§ Meticulous, with a proven ability
to meet deadlines
§ Twenty years of management experience
running the day-to-day operations of a Biostatistics Unit in a large academic
hospital setting
§ Award winning instructor of
introductory statistics courses for non-statisticians
§ Member of the Society for Clinical
Trials and the Statistical Society of Canada
§ Professional Statistician (P.
Stat.) designation awarded in 2008 by the Statistical Society of Canada
Jan. 2018 – present
Dalla
Lana School of Public Health
Assistant Professor / MSc Program
Director, Division of Biostatistics
§ Oversee the coordination and administration
of all aspects of the program
§ Teaching (CHL5210H, CHL5207Y, CHL5208Y)
§ New Course Development
§ Committee membership (Admissions and
Curriculum)
Jan. 1998 - present
Princess
Margaret Cancer Centre, University Health Network.
Manager, Biostatistics Department
§ Manage the day-to-day operations of a
biostatistics unit comprised of 10 biostatisticians and one SAS programmer
§ Allocate new requests to staff
§ Hire employees, monitor and evaluate staff
performance
§ Prepare annual budget and review finances
on a monthly basis
§ Oversee cost recovery process
Nov. 1985 - present
Princess
Margaret Cancer Centre, University Health Network.
§
Provide
experimental design and statistical analysis support in a collaborative
setting.
§
Prepare
and review statistical sections for abstracts/manuscripts.
§
Generate
reports detailing statistical design and analysis.
§
Participate
regularly at professional development meetings.
§
Provide
general consults
§
Teach
introductory biostatistics to residents and fellows
July 1, 2007 – December 31, 2018
Dalla Lana School of Public
Health, University of Toronto
Assistant
Professor (Status-Only)
§ Course director and instructor CHL5207/5208
from 2006 to present
§ MSc Admissions
Committee member from 2008 to present
§ Co-organizer of Biostatistics Workshop in
Cancer Research July 24-26, 2009
§ Tutorial leader for HAD 5303H: Controlled Clinical Trials from 2009 to 2015.
Oct. 2003 - June
30, 2007
Public Health Sciences
Department, Faculty of Medicine, University of Toronto
Adjunct Lecturer (Status Only)
§ Provided three lectures to Master’s level
students in Public Health (Community Health Appraisal Methods).
§ Assisted with marking and the design of the
final examination
§ Supervised student in Lab course 2004-2005
§ Invited talk “Guidelines for Reporting
Study Results” Lab Course Oct. 13, 2005
§ Introduction to Biostatistics (Research
methods course at U of T), March 6 and 13, 2006. Substituted for Jennifer Jones
(maternity leave).
§ Invited lecture March 12, 2007 – Research
Methods I course in Medical Radiation Sciences Program at U of T.
§ Helped co-ordinate and conduct CHL5207/5208
in 2006-2007
PROFESSIONAL
ASSOCIATIONS
§
Member,
Society for Clinical Trials since 1986.
§
Member,
Toronto Area Biostatistics Association since 1995.
§
Member,
Statistical Society of Canada since 2008.
§
Statistical
Reviewer for Clinical Oncology since
January 2001.
§
Statistical
Reviewer for Biology of Bone Marrow
Transplantation since Nov 2013
§
Member,
Canadian Blood and Marrow Transplant Group since March 2013.
§ 2016 Canadian Hematology Society Paper of the Year Award for “Pretreatment with anti-thymocyte globulin versus no anti-thymocyte globulin in patients with hematological malignancies undergoing haemopoietic cell transplantation from unrelated donors: a randomised, controlled, open-label, phase 3, multicentre trial” published in Lancet Oncology
1984
- 1985
Master of Science in Applied Statistics
University of Toronto.
1980 - 1984
Honour’s Bachelor of Science with a double major - statistics and
mathematics,
University of Toronto.
§ Experienced SAS user including completion
of several SAS Institute courses:
§ Bayesian Analysis in SAS (2011)
§ SAS Programming 2: Data Manipulation Techniques (2010)
§ SAS Programming 1: Essentials (2009)
§ Longitudinal data analysis with discrete
and continuous outcomes (2002)
§ Survival analysis using the Cox
proportional hazards model (2001)
§ Mixed models using PROC GLM and PROC MIXED
(2000)
§ SAS Macros (2000)
§ SAS Programming (1999)
§ Proficient with S-Plus (user since 1997)
with completion of Web-based courses:
o
Introduction
to GUI based system July 2000.
o
Command
Line Basics in April, 2000
§ R User since 2004.
o
Completed
a short course on R (York University in 2004).
o
Completed
Computing for Data Analysis, a short on-line course in R from Coursera, 2013.
§ Good familiarity with MS
WINDOWS, UNIX operating systems.
§ Wilson,
M. Victor Rodriguez-Freixinos; Tony
Panzarella; Katherine Karakasis; Amit M Oza Evolution in epithelial ovarian
cancer trials: improving accuracy by design. Submitted to Gynecologic Oncology.
§ Ferguson
SE, Panzarella T, Lau S, Gien LT, Samouëlian V, Giede C, Steed H, Le T,
Renkosinski B, Bernardini MQ. Prospective cohort study comparing quality of life
and sexual health outcomes between women undergoing robotic, laparoscopic and
open surgery for endometrial cancer. Gynecol Oncol. 2018 Apr 19. pii:
S0090-8258(18)30836-9. doi: 10.1016/j.ygyno.2018.04.558. [Epub ahead of print] PubMed
PMID: 29681461.
§ Yap ML,
Tieu M, Sappiatzer J, Panzarella T, Cuartero J, McCready D, Fyles A.
Outcomes
in Patients Treated with Post-mastectomy Chest Wall Radiotherapy without the
Routine Use of Bolus. Clin Oncol (R Coll Radiol). 2018 Mar 23. pii: S0936-6555(18)30165-1.
doi: 10.1016/j.clon.2018.03.005. [Epub ahead of print] PubMed PMID: 29580696.
§ Justyna Bartoszko, Tony Panzarella, Caroline McNamara, Anthea Lau, Aaron D Schimmer,
Andre Schuh, Hassan Sibai, Dawn Maze, Karen Yee, Rebecca Devlin, Vikas Gupta.
Distribution and Impact of Comorbidities on Survival and Leukemic
Transformation in Myeloproliferative Neoplasm-Associated Myelofibrosis: A
Retrospective Cohort Study. Clinical Lymphoma, Myeloma and Leukemia. In print.
§ Jay Spiegel, Caroline McNamara, James A.
Kennedy, Tony Panzarella, Andrea
Arruda, Tracy Stockley, Mahadeo Sukhai, Mariam Thomas, Justyna Bartoszko, Jenny
Ho, Nancy Siddiq, Dawn Maze, Aaron Schimmer, Andre Schuh, Hassan Sibai, Karen
Yee, Jamie Claudio, Rebecca Devlin, Mark Minden, Suzanne Kamel-Reid, and Vikas
Gupta. Impact of genomic alterations on outcomes in myelofibrosis patients
undergoing JAK1/2 inhibitor therapy. Blood
Advances. Volume 1, Number 20, pp. 1729-1738
§ Jennifer Y. Y. Kwan, Jennifer Croke, Tony Panzarella, Kuldesh Ubhi, Fei-Fei
Liu, Anthony Fyles, Anne Koch, Robert Dinniwell, Wilfred Levin, David McCready,
Caroline Chung, Jacqueline L. Bender. Assessing Supportive Care Needs and
Perceptions of Alternative Follow-up Care Options Among Well Breast Cancer
Patients: A Cross-sectional Survey. Journal
of Oncology Practice. Submitted.
§ Peter Chung, Martin O’Malley, Michael
Jewett, Philippe L. Bedard, Tony
Panzarella, Jeremy Sturgeon, Malcolm Moore, Robert Hamilton, Aaron R.
Hansen, Lynn Anson-Cartwright, Mary Gospodarowicz, Padraig Warde. Detection of
relapse by low dose CT during surveillance in stage I testicular germ cell
tumours. JNCI. To be submitted.
§ Kariminia, S. Ivison, Bernard Ng, J.
Rozmus, S. Sung, V. Avani, M. Aljurf, S. Lachance, I. Walker, C. Toze, J.
Lipton, S. J. Lee, J. Szer, R. Doocey, I. Lewis, L. Huebsch, M. Lalancette, C.
Smith, F. Almohareb, N. Chaudhri, M.K. Levings, R. Broady, G. Devins, D.
Szwajcer, R. Foley, Sara Mostafavi, D. Wall, S. Couban, T. Panzarella, and K. R. Schultz. CD56bright NK (NKreg) Cells in
Filgrastim Primed Donor Blood or Marrow Products Regulate Chronic GvHD: CBMTG
Randomized 0601 Study Results. Accepted
by Haematologica.
§ Long term responders to palliative
chemotherapy for advanced biliary tract cancer. Doherty MK, McNamara MG, Aneja
P, McInerney E, Moignard S, Horgan AM, Jiang H, Panzarella T, Jang R, Dhani N, Hedley D, Knox JJ. J Gastrointest
Oncol. 2017 Apr;8(2):352-360
§ Ottolino-Perry K, Chamma E, Blackmore KM,
Lindvere-Teene L, Starr D, Tapang K, Rosen CF, Pitcher B, Panzarella T, Linden R, DaCosta RS. Improved detection of
clinically relevant wound bacteria using autofluorescence image-guided sampling
in diabetic foot ulcers. Int Wound J.
2017 Feb 28. doi: 10.1111/iwj.12717. [Epub ahead of print]
§ Lheureux S, Lai Z, Dougherty BA, Runswick
S, Hodgson DR, Timms KM, Lanchbury JS, Kaye S, Gourley C, Bowtell D, Kohn EC,
Scott C, Matulonis U, Panzarella T,
Karakasis K, Burnier JV, Gilks CB, O'Connor MJ, Robertson JD, Ledermann J,
Barrett JC, Ho TW, Oza AM. Long-Term Responders on Olaparib Maintenance in
High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization. Clin
Cancer Res. 2017 Feb 21. doi: 10.1158/1078-0432.CCR-16-2615. [Epub ahead of
print].
§ Bouchard-Fortier G, Panzarella T, Rosen B, Chapman W, Gien LT. Endometrioid Carcinoma
of the Ovary: Outcomes Compared to Serous Carcinoma After 10 Years of
Follow-Up. J Obstet Gynaecol Can. 2017 Jan;39(1):34-41.
§ Richard PO, Alibhai SM, Panzarella T, Klotz L, Komisarenko M,
Fleshner N, Urbach , Finelli A. The uptake of active surveillance for the
management of prostate cancer: A population-based analysis. Can Urol Assoc J.
2016 Sep-Oct;10(9-10):E342-E346. Epub 2016 Oct 13.
§ Richard PO, Alibhai SM, Panzarella T, Klotz L, Komisarenko M,
Fleshner N, Urbach , Finelli A. The uptake of active surveillance for the
management of prostate cancer: A population-based analysis. Can Urol Assoc J.
2016 Sep-Oct;10(9-10):333-338.
§ Couban S, Aljurf M, Lachance S, Walker I,
Toze C, Rubinger M, Lipton JH, Lee SJ, Szer J, Doocey R, Lewis ID, Huebsch L,
Howson-Jan K, Lalancette M, Almohareb F, Chaudhri N, Ivison S, Broady R,
Levings M, Fairclough D, Devins G, Szwajcer D, Foley R, Smith C, Panzarella T, Kerr H, Kariminia A,
Schultz KR. Filgrastim-Stimulated Bone
Marrow compared with Filgrastim-Mobilized Peripheral Blood for Allografting in
Patients with Hematologic Malignancies. Biol Blood Marrow
Transplant. 2016 Oct 24
§
Köbel M, Atenafu EG, Rambau PF, Ferguson SE, Nelson GS, Ho TC, Panzarella T, McAlpine JN, Gilks CB,
Clarke BA, Bernardini MQ. Progesterone receptor expression is associated with
longer overall survival within high-grade histotypes of endometrial carcinoma:
A Canadian high risk endometrial cancer consortium (CHREC) study. Gynecol
Oncol. 2016 Apr 15. pii: S0090-8258(16)30109-3. doi:
10.1016/j.ygyno.2016.04.008. [Epub ahead of print] PMID: 27072807
§
Milosevic M, Angers C, Liszewski B, Drodge CS, Marchand EL, Bissonnette
JP, Brown E, Dunscombe P, Hunt J, Jiang H, Louie K, Mitera G, Moran K, Panzarella T, Parliament M,
Ross S, Brundage M. The Canadian National System for
Incident Reporting in Radiation Treatment (NSIR-RT) Taxonomy. Pract Radiat Oncol.
2016 Jan 30. pii: S1879-8500(16)00046-1. doi: 10.1016/j.prro.2016.01.013. [Epub
ahead of print]
§
Kariminia A, Holtan SG, Ivison S, Rozmus J, Hebert MJ, Martin PJ,
Lee SJ, Wolff D, Subrt P, Abdossamadi S, Sung S, Storek J, Levings M, Aljurf M,
Arora M, Cutler C, Gallagher G, Kuruvilla J, Lipton J, Nevill TJ, Newell
LF, Panzarella T, Pidala J, Popradi G, Szwajcer D, Tay J, Toze CL,
Walker I, Couban S, Storer BE, Schultz KR. Heterogeneity of chronic
graft-versus-host disease biomarkers: the only consistent association is with
CXCL10 and CXCR3+ NK cells. Blood. 2016 Mar 28. pii: blood-2015-09-668251.
[Epub ahead of print] PMID: 27020088
§
Bernardini
MQ, Gien LT, Lau S, Altman AD, Gilks B, Ferguson SE, Köbel M, Samouëlian V,
Wesa M, Cameron A, Nelson G, Han G, Clarke B, Ho TC, Panzarella T, Atenafu EG, McAlpine JN. Treatment related outcomes
in high-risk endometrial carcinoma: Canadian high risk endometrial cancer
consortium (CHREC). Gynecol Oncol. 2016 Apr;141(1):148-54. doi:
10.1016/j.ygyno.2016.02.002. Epub 2016 Feb 5. PMID: 26854651
§ Walker I, Panzarella T, Couban S, Couture F, Devins G, Elemary M, Gallagher G, Kerr H, Kuruvilla J, Lee SJ, Moore J, Nevill T, Popradi G, Roy J, Schultz KR, Szwajcer D, Toze C, Foley R; Canadian Blood and Marrow Transplant Group. Pretreatment with anti-thymocyte globulin versus no anti-thymocyte globulin in patients with hematological malignancies undergoing haemopoietic cell transplantation from unrelated donors: a randomised, controlled, open-label, phase 3, multicentre trial. Lancet Oncol. 2016 Feb;17(2):164-73. doi: 10.1016/S1470-2045(15)00462-3. Epub 2015 Dec 24.
§ Bartoszko J, Panzarella T, Lau A, Schimmer A, Schuh A, Shanavas M, Yee K, Gupta
V. Impact of Red-cell transfusion requiring anemia on the natural history of
Myeloproliferative Neoplasm-associated Myelofibrosis. Clin Lymphoma Myeloma
Leuk. 2015 Nov;15(11):e151-6. doi: 10.1016/j.clml.2015.09.001. Epub 2015 Sep
21. PMID: 26566925
§ Altman AD, Ferguson SE, Atenafu EG, Köbel
M, McAlpine JN, Panzarella T, Lau S,
Gien LT, Gilks B, Clarke B, Cameron A, Nelson G, Han G, Samouëlian V, Ho TC, Louie
K, Bernardini MQ. Canadian high risk endometrial cancer (CHREC) consortium: Analyzing
the clinical behaviour of high risk endometrial cancers. Gynecol Oncol. 2015
Sep 6. pii: S0090-8258(15)30119-0. doi: 10.1016/j.ygyno.2015.09.001. [Epub ahead
of print] PubMed PMID: 26352641.
§ Hsu T, Black PC, Chi KN, Canil CM, Eigl BJ,
Kulkarni G, North S, Wood L, Zlotta AR, Lau A, Panzarella
T, Sridhar SS. Treatment
of muscle-invasive bladder cancer in Canada: A survey of genitourinary medical
oncologists and urologists. Can Urol Assoc J. 2014 Sep;8(9-10):309-16. doi:
10.5489/cuaj.2111. PubMed PMID: 25408794; PubMed Central PMCID: PMC4216285.
§ Salmasi G, Li M, Sivabalasundaram V, Panzarella T, Tsang R, Kukreti V, Crump
M, Kuruvilla J. Incidence of Pneumonitis in patients with non-Hodgkin Lymphoma receiving
§ Chemoimmunotherapy with Rituximab. Leuk
Lymphoma. 2014 Oct 30:1-19. [Epub ahead of print] PubMed PMID: 25356925.
§ Kuo KH, Callum JL, Panzarella T, Jacks LM, Brandwein J,
Crump M, Curtis JE, Gupta V,
Lipton JH, Minden MD, Sher GD, Schimmer AD, Schuh AC, Yee KW, Keating A,
Messner HA. A retrospective observational study of leucoreductive strategies to
manage patients with acute myeloid leukaemia presenting with hyperleucocytosis.
Br J Haematol. 2015 Feb;168(3):384-94. doi: 10.1111/bjh.13146. Epub 2014 Oct
10. PubMed PMID: 25303497.
§ Chung P, Daugaard G, Tyldesley S, Atenafu
EG, Panzarella T, Kollmannsberger C,
Warde P. Evaluation of a prognostic model for risk of relapse in stage I
seminoma surveillance. Cancer Med. 2015 Jan;4(1):155-60. doi: 10.1002/cam4.324.
Epub 2014 Sep 19. PubMed PMID: 25236854; PubMed Central PMCID: PMC4312129.
§ Villa D,
George A, Seymour JF, Toze CL, Crump M, Lee C, Buckstein R, Stewart DA,
MacDonald D, Foley R, Xenocostas A, Sabloff M, Chua N, Couture F, Larouche JF,
Cohen S, Savage KJ, Connors JM, Panzarella
T, Carney DA, Dickinson M, Kuruvilla J. Favorable Outcomes from Allogeneic
and Autologous Stem CellTransplantation for Patients with Transformed
Non-Follicular Indolent Lymphoma.Biol Blood Marrow Transplant. 2014 Jul 17.
pii: S1083-8791(14)00441-8. doi: 10.1016/j.bbmt.2014.07.015. [Epub ahead of
print] PubMed PMID: 25042735.
§ EBCTCG
(Early Breast Cancer Trialists' Collaborative Group), McGale P, Taylor C,
Correa C, Cutter D, Duane F, Ewertz M, Gray R, Mannu G, Peto R, Whelan T, Wang Y,
Wang Z, Darby S. Effect of radiotherapy after mastectomy and axillary surgery
on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual
patient data for 8135 women in 22 randomised trials. Lancet. 2014 Jun
21;383(9935):2127-35. doi: 10.1016/S0140-6736(14)60488-8. Epub 2014 Mar 19. Erratum
in: Lancet. 2014 Nov 22;384(9957):1848. PubMed PMID: 24656685.
§ Tsoref D, Panzarella T, Oza A. Aspirin in
prevention of ovarian cancer: are we at the tipping point? J Natl Cancer Inst.
2014 Feb;106(2): djt453. doi: 10.1093/jnci/djt453. PubMed PMID: 24503201.
§ Zhong T,
Temple-Oberle C, Hofer S, Beber B, Semple J, Brown M, Macadam S, Lennox P, Panzarella T, McCarthy C, Baxter N;
MCCAT Study Group. The Multi Centre Canadian Acellular Dermal Matrix Trial
(MCCAT): study protocol for a randomized controlled trial in implant-based
breast reconstruction. Trials. 2013 Oct 28; 14:356. doi:
10.1186/1745-6215-14-356. PubMed PMID: 24165392; PubMed Central PMCID:
PMC3842809.
§ Zih FS,
Wong-Chong N, Hummel C, Petronis J, Panzarella
T, Pollett A, McCart JA, Swallow CJ. Erratum to: Mucinous Tumor of the
Appendix with Limited Peritoneal Spread: Is There a Role for Expectant
Observation? Ann Surg Oncol. 2013 Oct 26. [Epub ahead of print] PubMed PMID:
24162841.
§ Zih FS,
Wong-Chong N, Hummel C, Petronis J, Panzarella
T, Pollett A, McCart AJ, Swallow CJ. Mucinous tumor of the appendix with
limited peritoneal spread: is there a role for expectant observation? Ann Surg
Oncol. 2014 Jan;21(1):225-31. doi: 10.1245/s10434-013-3283-0. Epub 2013 Oct 8.
PubMed PMID: 24100959.
§ Panzarella T, Villa D, Kuruvilla
J. Reply to C.s. Tam et Al. J Clin Oncol.
2013 Sep
1;31(25):3167-8. doi: 10.1200/JCO.2013.51.0537. Epub 2013 Aug 5. PubMed PMID:
23943832.
§ Leung E,
Warde P, Jewett M, Panzarella T,
O'Malley M, Sweet J, Moore M,
Sturgeon J,
Gospodarowicz M, Chung P. Treatment burden in stage I seminoma: a comparison of
surveillance and adjuvant radiation therapy. BJU
Int. 2013
Dec
;112(8) :1088-95. doi: 10.1111/bju.12330. Epub 2013 Aug 13.
PubMed PMID:
23937685.
§ Gerrie AS,
Mikhael JR, Cheng L, Jiang H, Kukreti V, Panzarella
T, Reece D,
Stewart KA, Trieu Y,
Trudel S, Chen CI. D(T)PACE as salvage therapy for
aggressive or
refractory multiple myeloma. Br J Haematol. 2013 Jun;161(6):802-doi:
10.1111/bjh.12325. Epub 2013 Apr 18. PubMed PMID: 23594335.
§ Villa D,
Crump M, Keating A, Panzarella T,
Feng B, Kuruvilla J. Outcome of
patients with
transformed indolent non-Hodgkin lymphoma referred for autologous stem-cell
transplantation. Ann Oncol. 2013 Jun;24(6):1603-9. doi:
10.1093/annonc/mdt029.
Epub 2013 Feb 20. PubMed PMID: 23425946.
§ Villa D,
Crump M, Panzarella T, Savage KJ,
Toze CL, Stewart DA, MacDonald DA,Buckstein R, Lee C, Alzahrani M, Rubinger M,
Foley R, Xenocostas A, Sabloff M, Muccilli A, Chua N, Couture F, Larouche JF,
Cohen S, Connors JM, Ambler K,
Al-Tourah A, Ramadan
KM, Kuruvilla J. Autologous and allogeneic stem-cell
transplantation for
transformed follicular lymphoma: a report of the Canadian
blood and marrow
transplant group. J Clin Oncol. 2013 Mar 20;31(9):1164-71. doi:
10.1200/JCO.2012.44.0693. Epub 2013 Feb 11. PubMed PMID: 23401459.
§ Kim D,
Al-Dawsari G, Chang H, Panzarella T,
Gupta V, Kuruvilla J, Lipton JH,
Messner HA. Large
granular lymphocytosis and its impact on long-term clinical
outcomes following
allo-SCT. Bone Marrow Transplant. 2013 Aug;48(8):1104-11.
doi:10.1038/bmt.2013.5. Epub 2013 Feb 11. PubMed PMID: 23396405.
§ Wong RK,
Letourneau D, Varma A, Bissonnette JP, Fitzpatrick D, Grabarz D,
Elder C, Martin M,
Bezjak A, Panzarella T,
Gospodarowicz M, Jaffray DA. A
one-step cone-beam
CT-enabled planning-to-treatment model for palliative
radiotherapy-from
development to implementation. Int J Radiat Oncol Biol Phys.
2012 Nov
1;84(3):834-40. doi: 10.1016/j.ijrobp.2012.01.025. Epub 2012 May 15.
PubMed PMID: 22592043.
§ Vesprini D,
Chung P, Tolan S, Gospodarowicz M, Jewett M, O'Malley M, Sweet J, Moore M, Panzarella T, Sturgeon J, Sugar L,
Anson-Cartwright L, Warde P. Utility of serum tumor markers during surveillance
for stage I seminoma. Cancer. 2012 Nov 1;118(21):5245-50. doi:
10.1002/cncr.27539. Epub 2012 Apr 19. PubMed PMID:22517478.
§ Early
Breast Cancer Trialists' Collaborative Group (EBCTCG), Darby S, McGale
P, Correa C, Taylor C,
Arriagada R, Clarke M, Cutter D, Davies C, Ewertz M,
Godwin J, Gray R,
Pierce L, Whelan T, Wang Y, Peto R. Effect of radiotherapy
after
breast-conserving surgery on 10-year recurrence and 15-year breast cancer
death: meta-analysis
of individual patient data for 10,801 women in 17 randomised trials. Lancet.
2011 Nov 12;378(9804):1707-16. doi:
10.1016/S0140-6736(11)61629-2.
Epub 2011 Oct 19. Review. PubMed PMID: 22019144; PubMed Central PMCID:
PMC3254252.
§ Early
Breast Cancer Trialists' Collaborative Group (EBCTCG), Davies C, Godwin
J, Gray R, Clarke M,
Cutter D, Darby S, McGale P, Pan HC, Taylor C, Wang YC,
Dowsett M, Ingle J,
Peto R. Relevance of breast cancer hormone receptors and
other factors to the
efficacy of adjuvant tamoxifen: patient-level meta-analysis
of randomised trials.
Lancet. 2011 Aug 27;378(9793):771-84. doi:
10.1016/S0140-6736(11)60993-8.
Epub 2011 Jul 28. PubMed PMID: 21802721; PubMed Central PMCID: PMC3163848.
§ Gupta V, Panzarella T, Li L,
Khan J, Sharma A, Lipton JH, Kuruvilla J,
Messner H, Alibhai SM.
A prospective study comparing the outcomes and
health-related quality
of life in adult patients with myeloid malignancies
undergoing allogeneic
transplantation using myeloablative or reduced-intensity
conditioning. Biol
Blood Marrow Transplant. 2012 Jan;18(1):113-24. doi:
10.1016/j.bbmt.2011.05.022.
Epub 2011 Jun 12. PubMed PMID: 21703974.
§ Edelstein
K, Spiegler BJ, Fung S, Panzarella T,
Mabbott DJ, Jewitt N,
D'Agostino
NM, Mason WP, Bouffet E, Tabori U, Laperriere N, Hodgson DC. Early aging
in adult survivors of childhood medulloblastoma: long-term neurocognitive,
functional, and physical outcomes. Neuro Oncol. 2011 May;13(5):536-45. doi: 10.1093/neuonc/nor015.
Epub 2011 Mar 2. PubMed PMID: 21367970; PubMed Central PMCID: PMC3093335.
§ Mazrani W,
O'Malley ME, Chung PW, Warde P, Vesprini D, Panzarella T. Lymph node growth rate in testicular germ cell
tumours: implications for computed tomography surveillance frequency. Clin
Oncol (R Coll Radiol). 2011 Jun;23(5):333-8. doi: 10.1016/j.clon.2010.10.006.
Epub 2010 Nov 16. PubMed PMID: 21084179.
§ Sia MA, Tsang RW, Panzarella T,
Brierley JD. Differentiated thyroid cancer
with extrathyroidal
extension: prognosis and the role of external beam radiotherapy. J Thyroid Res.
2010 May 6; 2010:183461. doi: 10.4061/2010/183461. PubMed PMID: 21048835;
PubMed Central PMCID: PMC2956971.
§ Early
Breast Cancer Trialists' Collaborative Group (EBCTCG), Correa C, McGale
P, Taylor C, Wang Y,
Clarke M, Davies C, Peto R, Bijker N, Solin L, Darby S.
Overview of the
randomized trials of radiotherapy in ductal carcinoma in situ of
the breast. J Natl
Cancer Inst Monogr. 2010;2010(41):162-77. doi:
10.1093/jncimonographs/lgq039.
Review. PubMed PMID: 20956824.
§ Grabarz D, Panzarella T, Bezjak A, Mclean M, Elder
C, Wong RK. Quantifying interobserver variation in target definition in
palliative radiotherapy. Int J Radiat Oncol Biol Phys. 2011 Aug
1;80(5):1498-504. doi: 10.1016/j.ijrobp.2010.04.014. Epub 2010 Jul 23. PubMed
PMID: 20656422.
§ Higgins J,
Bezjak A, Hope A, Panzarella T, Li
W, Cho JB, Craig T, Brade A, Sun A, Bissonnette JP. Effect of image-guidance
frequency on geometric accuracy and setup margins in radiotherapy for locally
advanced lung cancer. Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1330-7.
doi: 10.1016/j.ijrobp.2010.04.006. Epub 2010 Jul 17. PubMed PMID: 20643515.
§ Dickie CI,
Parent AL, Chung PW, Catton CN, Craig T, Griffin AM, Panzarella T,
Ferguson PC, Wunder
JS, Bell RS, Sharpe MB, O'Sullivan B. Measuring interfractional and
intrafractional motion with cone beam computed tomography and an optical
localization system for lower extremity soft tissue sarcoma patients treated with
preoperative intensity-modulated radiation therapy. Int J Radiat Oncol Biol
Phys. 2010 Dec 1;78(5):1437-44. doi: 10.1016/j.ijrobp.2009.09.054. Epub 2010
Mar 28. PubMed PMID: 20350788.
§ O'Malley
ME, Chung P, Haider M, Jang HJ, Jhaveri K, Khalili K, Panzarella T,
Warde P. Comparison of
low dose with standard dose abdominal/pelvic multidetector CT in patients with
stage 1 testicular cancer under surveillance. Eur Radiol. 2010
Jul;20(7):1624-30. doi: 10.1007/s00330-009-1710-1. Epub 2010 Jan 30. PubMed
PMID: 20119727.
§ Dickie CI,
Parent A, Griffin A, Craig T, Catton C, Chung P, Panzarella T, O'Sullivan B, Sharpe M. A device and procedure for
immobilization of patients receiving limb-preserving radiotherapy for soft
tissue sarcoma. Med Dosim. 2009 Fall;34(3):243-9. doi:
10.1016/j.meddos.2008.10.003. Epub 2008 Nov 24. PubMed PMID: 19647636.
§ Wheatley-Price
P, Massey C, Panzarella T, Shepherd
FA, Mikhael J. Resident preparedness in discussing prognosis in patients with
advanced lung cancer.Support Care Cancer. 2010 Apr;18(4):491-7. doi:
10.1007/s00520-009-0702-7. Epub 2009 Jul 21. PubMed PMID: 19629536.
§ Tolan S,
Vesprini D, Jewett MA, Warde PR, O'Malley M, Panzarella T, Sturgeon
JF, Moore M,
Tew-George B, Gospodarowicz MK, Chung PW. No role for routine chest radiography
in stage I seminoma surveillance. Eur Urol. 2010 Mar;57(3):474-9. doi:
10.1016/j.eururo.2009.06.029. Epub 2009 Jun 26. PubMed PMID: 19577354.
§ Alshumrani
G, O'Malley M, Ghai S, Metser U, Kachura J, Finelli A, Mattar K, Panzarella T. Small (< or = 4 cm)
cortical renal tumors: characterization with multidetector CT. Abdom Imaging.
2010 Aug;35(4):488-93. doi: 10.1007/s00261-009-9546-3. Epub 2009 Jun 18. PubMed
PMID: 19536589.
§ Armel SR,
McCuaig J, Finch A, Demsky R, Panzarella
T, Murphy J, Rosen B. The effectiveness of family history questionnaires in
cancer genetic counseling. J Genet Couns. 2009 Aug;18(4):366-78. doi:
10.1007/s10897-009-9228-x. Epub 2009 May 21. PubMed PMID: 19459037.
§ Dougherty
E, Pierce B, Ma C, Panzarella T,
Rodin G, Zimmermann C. Factors associated with work stress and professional
satisfaction in oncology staff. Am J Hosp Palliat Care. 2009
Apr-May;26(2):105-11. doi: 10.1177/1049909108330027. Epub 2009 Jan 14. PubMed
PMID: 19144993.
§ Chow E,
Abdolell M, Panzarella T, Harris K,
Bezjak A, Warde P, Tannock I. Predictive model for survival in patients with
advanced cancer. J Clin Oncol. 2008 Dec 20 ;26(36):5863-9. doi: 10.1200/JCO.2008.17.1363. Epub 2008
Nov 17. PubMed PMID: 19018082.
§ Chow E,
Abdolell M, Panzarella T, Harris K,
Bezjak A, Warde P, Tannock I. Recursive partitioning analysis of prognostic
factors for survival in patients with advanced cancer. Int J Radiat Oncol Biol
Phys. 2009 Mar 15;73(4):1169-76. doi: 10.1016/j.ijrobp.2008.05.067. Epub 2008
Oct 19. PubMed PMID: 18938045.
§ Chow E,
Abdolell M, Panzarella T, Harris K,
Bezjak A, Warde P, Tannock I. Validation of a predictive model for survival in
metastatic cancer patients attending an outpatient palliative radiotherapy
clinic. Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):280-7. doi:
10.1016/j.ijrobp.2008.03.019. PubMed PMID: 18676092.
§ Rafferty
MA, Goldstein DP, Rotstein L, Asa SL, Panzarella
T, Gullane P, Gilbert RW, Brown DH, Irish JC. Completion thyroidectomy
versus total thyroidectomy: is there a difference in complication rates? An
analysis of 350 patients. J Am Coll Surg. 2007 Oct;205(4):602-7. PubMed PMID:
17903736.
§ Milosevic
M, Chung P, Parker C, Bristow R, Toi A, Panzarella
T, Warde P, Catton C, Menard C, Bayley A, Gospodarowicz M, Hill R. Androgen
withdrawal in patients reduces prostate cancer hypoxia: implications for
disease progression and radiation response. Cancer Res. 2007 Jul
1;67(13):6022-5. PubMed PMID: 17616657.
§ Pierce B,
Dougherty E, Panzarella T, Le LW,
Rodin G, Zimmermann C. Staff stress, work satisfaction, and death attitudes on
an oncology palliative care unit, and on a medical and radiation oncology
inpatient unit. J Palliat Care. 2007 Spring;23(1):32-9. PubMed PMID: 17444460.
§ Martin JM, Panzarella T, Zwahlen DR, Chung P,
Warde P. Evidence-based guidelines for following stage 1 seminoma. Cancer. 2007
Jun 1;109(11):2248-56. PubMed PMID: 17437287.
§ Wannesson
L, Panzarella T, Mikhael J, Keating
A. Feasibility and safety of autotransplants with noncryopreserved marrow or
peripheral blood stem cells: a systematic review. Ann Oncol. 2007
Apr;18(4):623-32. Epub 2007 Mar 12. Review. PubMed PMID: 17355952.
§ Chow E,
Loblaw A, Harris K, Doyle M, Goh P, Chiu H, Panzarella T, Tsao M, Barnes EA, Sinclair E, Farhadian M, Danjoux
C. Dexamethasone for the prophylaxis of radiation-induced pain flare after
palliative radiotherapy for bone metastases: a pilot study. Support Care
Cancer. 2007 Jun;15(6):643-7. Epub 2007 Jan 23. PubMed PMID: 17242910.
§ Loblaw DA,
Wu JS, Kirkbride P, Panzarella T,
Smith K, Aslanidis J, Warde P. Pain flare in patients with bone metastases
after palliative radiotherapy—a nested randomized control trial. Support Care
Cancer. 2007 Apr;15(4):451-5. Epub 2006 Nov 9. PubMed PMID: 17093912.
§ Kuruvilla J, Song K, Mollee P, Panzarella
T, McCrae J, Nagy T, Crump M, Keating A. A phase II study of
thalidomide and vinblastine for palliative
patients
with Hodgkin's lymphoma. Hematology. 2006 Feb;11(1):25-9. PubMed PMID: 16522545.
§ Brierley J,
Tsang R, Panzarella T, Bana N.
Prognostic factors and the effect of treatment with radioactive iodine and
external beam radiation on patients with differentiated thyroid cancer seen at
a single institution over 40 years. Clin Endocrinol (Oxf). 2005
Oct;63(4):418-27. PubMed PMID: 16181234.
§ Chow E,
Ling A, Davis L, Panzarella T,
Danjoux C. Pain flare followingexternal beam radiotherapy and meaningful change
in pain scores in the treatment of bone metastases. Radiother Oncol. 2005
Apr;75(1):64-9. Epub 2005 Mar 16. PubMed PMID: 15878102.
§ Chow E,
Davis L, Panzarella T, Hayter C,
Szumacher E, Loblaw A, Wong R, Danjoux C. Accuracy of survival prediction by
palliative radiation oncologists. Int J Radiat Oncol Biol Phys. 2005 Mar
1;61(3):870-3. PubMed PMID: 15708268.
§ Shier LR,
Schultz KR, Imren S, Regan J, Issekutz A, Sadek I, Gilman A, Luo Z, Panzarella T, Eaves CJ, Couban S.
Differential effects of granulocyte colony-stimulating factor on marrow- and
blood-derived hematopoietic and immune cell populations in healthy human
donors. Biol Blood Marrow Transplant. 2004 Sep;10(9):624-34. PubMed PMID:
15319774.
§ Yi Q, Panzarella T, Corey P. Incorporating
the sampling variation of the disease prevalence when calculating the sample
size in a study to determine the diagnostic accuracy of a test. Control Clin
Trials. 2004 Aug;25(4):417-27. PubMed PMID: 15296816.
§ Chung PW,
Gospodarowicz MK, Panzarella T,
Jewett MA, Sturgeon JF, Tew-George B, Bayley AJ, Catton CN, Milosevic MF, Moore
M, Warde PR. Stage II testicular seminoma: patterns of recurrence and outcome
of treatment. Eur Urol. 2004 Jun;45(6):754-59; discussion 759-60. PubMed PMID:
15149748.
§ Bredeson C,
Leger C, Couban S, Simpson D, Huebsch L, Walker I, Shore T, Howson-Jan K, Panzarella T, Messner H, Barnett M,
Lipton J. An evaluation of the donor experience in the canadian multicenter
randomized trial of bone marrow versus peripheral blood allografting. Biol
Blood Marrow Transplant. 2004 Jun;10(6):405-14. PubMed PMID: 15148494.
§ Crook J,
Milosevic M, Catton P, Yeung I, Haycocks T, Tran T, Catton C, McLean M, Panzarella T, Haider MA. Interobserver
variation in postimplant computed tomography contouring affects quality
assessment of prostate brachytherapy. Brachytherapy. 2002;1(2):66-73. PubMed
PMID: 15062173.
§ Parker C,
Milosevic M, Toi A, Sweet J, Panzarella
T, Bristow R, Catton C, Catton P, Crook J, Gospodarowicz M, McLean M, Warde
P, Hill RP. Polarographic electrode study of tumor oxygenation in clinically
localized prostate cancer. Int J Radiat Oncol Biol Phys. 2004 Mar
1;58(3):750-7. PubMed PMID: 14967430.
§ Volpe A, Panzarella T, Rendon RA, Haider MA,
Kondylis FI, Jewett MA. The natural history of incidentally detected small
renal masses. Cancer. 2004 Feb 15;100(4):738-45. PubMed PMID: 14770429.
§ Parker C,
Warde P, Norman A, Panzarella T,
Catton C, Horwich A, Huddart R, Dearnaley D. The role of hemoglobin
concentration in clinically localized prostate cancer treated with radical
radiotherapy +/- neoadjuvant androgen deprivation. Int J Radiat Oncol Biol
Phys. 2004 Jan 1;58(1):53-8. PubMed PMID: 14697420.
§ Chung PW,
Warde PR, Panzarella T, Bayley AJ,
Catton CN, Milosevic MF, Jewett MA, Sturgeon JF, Moore M, Gospodarowicz MK.
Appropriate radiation volume for stage IIA/B testicular seminoma. Int J Radiat
Oncol Biol Phys. 2003 Jul 1;56(3):746-8. PubMed PMID: 12788180.
§ Kiss TL, Panzarella T, Messner HA, Meharchand J,
Reddy V, Schimmer AD, Lipton JH. Busulfan and cyclophosphamide as a preparative
regimen for allogeneic blood and marrow transplantation in patients with
non-Hodgkin's lymphoma. Bone Marrow Transplant. 2003 Jan;31(2):73-8. PubMed
PMID: 12621486.
§ Warde P,
Specht L, Horwich A, Oliver T, Panzarella
T, Gospodarowicz M, vonder Maase H. Prognostic factors for relapse in stage
I seminoma managed by surveillance: a pooled analysis. J Clin Oncol. 2002 Nov
15;20(22):4448-52. PubMed PMID: 12431967.
§ Chung P,
Parker C, Panzarella T,
Gospodarowicz MK, Jewett S, Milosevic MF,Catton CN, Bayley AJ, Tew-George B,
Moore M, Sturgeon JF, Warde P. Surveillance in stage I testicular seminoma -
risk of late relapse. Can J Urol. 2002 Oct;9(5):1637-40. PubMed PMID: 12431325.
§ Yi Q, Panzarella T. Estimating sample size
for tests on trends across repeated measurements with missing data based on the
interaction term in a mixed model. Control Clin Trials. 2002 Oct;23(5):481-96.
PubMed PMID: 12392862.
§ Parker C,
Milosevic M, Panzarella T, Banerjee
D, Jewett M, Catton C, Tew-George B, Gospodarowicz M, Warde P. The prognostic
significance of the tumour infiltrating lymphocyte count in stage I testicular
seminoma managed by Surveillance. Eur J Cancer. 2002 Oct ;38(15) :2014-9.
PubMed
PMID: 12376206.
§ Isaac N, Panzarella T, Lau A, Mayers C,
Kirkbride P, Tannock IF, Vallis KA. Concurrent cyclophosphamide, methotrexate,
and 5-fluorouracil chemotherapy and radiotherapy for breast carcinoma: a well-tolerated
adjuvant regimen. Cancer. 2002 Aug 15;95(4):696-703. PubMed PMID: 12209711.
§ Couban S,
Simpson DR, Barnett MJ, Bredeson C, Hubesch L, Howson-Jan K, Shore TB, Walker
IR, Browett P, Messner HA, Panzarella T,
Lipton JH; Canadian Bone Marrow Transplant Group. A randomized multicenter
comparison of bone marrow and peripheral blood in recipients of matched sibling
allogeneic transplants for myeloid malignancies. Blood. 2002 Sep
1;100(5):1525-31. PubMed PMID: 12176866.
§ McCarthy
JS, Tannock IF, Degendorfer P, Panzarella
T, Furlan M, Siu LL. A Phase II trial of docetaxel and cisplatin in
patients with recurrent or metastatic nasopharyngeal carcinoma. Oral Oncol.
2002 Oct;38(7):686-90. PubMed PMID: 12167421.
§ Chow E,
Fung K, Panzarella T, Bezjak A,
Danjoux C, Tannock I. A predictive model for survival in metastatic cancer
patients attending an outpatient palliative radiotherapy clinic. Int J Radiat
Oncol Biol Phys. 2002 Aug 1;53(5):1291-302. PubMed PMID: 12128132.
§ Tsao MN,
Tsang RW, Liu FF, Panzarella T,
Rotstein L. Radiotherapy management for squamous cell carcinoma of the nasal
skin: the Princess Margaret Hospital experience. Int J Radiat Oncol Biol Phys.
2002 Mar 15;52(4):973-9. PubMed PMID: 11958891.
§ Catton C,
Gospodarowicz M, Mui J, Panzarella T,
Milosevic M, McLean M, Catton P, Warde P. Clinical and biochemical outcome of
conventional dose radiotherapy for localized prostate cancer. Can J Urol. 2002
Feb;9(1):1444-52; discussion 1453. PubMed PMID: 11886597.
§ Bezjak A,
Adam J, Barton R, Panzarella T,
Laperriere N, Wong CS, Mason W, Buckley C, Levin W, McLean M, Wu JS, Sia M,
Kirkbride P. Symptom response after palliative radiotherapy for patients with
brain metastases. Eur J Cancer. 2002 Mar;38(4):487-96. PubMed PMID: 11872340.
§ Crook J,
Grimard L, Tsihlias J, Morash C, Panzarella
T. Interstitial brachytherapy for penile cancer: an alternative to
amputation. J Urol. 2002 Feb;167(2 Pt 1):506-11. PubMed PMID: 11792907.
§ Brierley
JD, Catton PA, O'Sullivan B, Dancey JE, Dowling AJ, Irish JC, McGowan TS,
Sturgeon JF, Swallow CJ, Rodrigues GB, Panzarella
T. Accuracy of recorded tumor, node, and metastasis stage in a
comprehensive cancer center. J Clin Oncol. 2002 Jan 15;20(2):413-9. PubMed
PMID: 11786568.
§ Bezjak A,
Adam J, Panzarella T, Levin W,
Barton R, Kirkbride P, McLean M, Mason W, Wong CS, Laperriere N. Radiotherapy
for brain metastases: defining palliative response. Radiother Oncol. 2001
Oct;61(1):71-6. PubMed PMID: 11578731.
§ Brierley J,
Wong CS, Cummings B, Catton P, Ringash J, Catton C, McLean M, Keane T, Panzarella T. Squamous cell carcinoma
of the oesophagus treated with radiation and 5-fluorouracil, with and without
mitomycin C. Clin Oncol (R Coll Radiol). 2001;13(3):157-63. PubMed PMID:
11527287.
§ Dowling AJ,
Panzarella T, Ernst DS, Neville AJ,
Moore MJ, Tannock IF. A retrospective analysis of the relationship between
changes in serum PSA, palliative response and survival following systemic
treatment in a Canadian randomized trial for symptomatic hormone-refractory
prostate cancer. Ann Oncol. 2001 Jun;12(6):773-8. PubMed PMID: 11484951.
§ Mayers C, Panzarella T, Tannock IF. Analysis of
the prognostic effects of inclusion in a clinical trial and of myelosuppression
on survival after adjuvant chemotherapy for breast carcinoma. Cancer. 2001 Jun
15;91(12):2246-57. PubMed PMID: 11413512.
§ Catton C,
Gospodarowicz M, Warde P, Panzarella T,
Catton P, McLean M, Milosevic M. Adjuvant and salvage radiation therapy after
radical prostatectomy for adenocarcinoma of the prostate. Radiother Oncol. 2001
Apr;59(1):51-60. PubMed PMID: 11295206.
§ Warde P,
Gospodarowicz MK, Panzarella T, Chow
E, Murphy T, Catton CN, Sturgeon JF, Moore M, Milosevic M, Jewett MA. Long term
outcome and cost in the management of stage I testicular seminoma. Can J Urol.
2000 Apr;7(2):967-72; discussion 973.. PubMed PMID: 11119439.
§ Rendon RA,
Stanietzky N, Panzarella T,
Robinette M, Klotz LH, Thurston W, Jewett MA. The natural history of small
renal masses. J Urol. 2000 Oct;164(4):1143-7. PubMed PMID: 10992354.
§ Patterson
BJ, Freedman J, Blanchette V, Sher G, Pinkerton P, Hannach B, Meharchand J, Lau
W, Boyce N, Pinchefsky E, Tasev T, Pinchefsky J, Poon S, Shulman L, MacK P,
Thomas K, Blanchette N, Greenspan D, Panzarella
T. Effect of premedication guidelines and leukoreduction on the rate of
febrile nonhaemolytic platelet transfusion reactions. Transfus Med. 2000
Sep;10(3):199-206. PubMed PMID: 10972914.
§ Silva JJ,
Tsang RW, Panzarella T, Levin W,
Wells W. Results of radiotherapy for epithelial skin cancer of the pinna: The
Princess Margaret Hospital experience, 1982-1993. Int J Radiat Oncol Biol Phys.
2000 May 1;47(2):451-9. PubMed PMID: 10802373.
§ McGowan TS,
Cummings BJ, O'Sullivan B, Catton CN, Miller N, Panzarella T. An analysis of 78 breast sarcoma patients without
distant metastases at presentation. Int J Radiat Oncol Biol Phys. 2000 Jan
15;46(2):383-90. PubMed PMID: 10661345.
§ McLean M,
Chow E, O'Sullivan B, Munro A, Leung PM, Loblaw DA, Panzarella T. Re-irradiation for locally recurrent nasopharyngeal
carcinoma. Radiother Oncol. 1998 Aug;48(2):209-11. PubMed PMID: 9783894.
§
Panzarella
T, Meakin JW. Analysis of cause-specific failure endpoints using simple
proportions: an example from a randomized controlled clinical trial in early
breast cancer. Int J Radiat Oncol Biol Phys. 1998 Jul 15;41(5):1093-7. PubMed
PMID: 9719120.
§
Hodgson DC, Brierley JD, Tsang RW, Panzarella T. Prescribing 131Iodine
based on neck uptake produces effective thyroid ablation and reduced hospital
stay. Radiother Oncol. 1998 Jun;47(3):325-30. PubMed PMID: 9681898.
§ Bloomfield
DJ, Krahn MD, Neogi T, Panzarella T,
Smith TJ, Warde P, Willan AR, Ernst S, Moore MJ, Neville A, Tannock IF.
Economic evaluation of chemotherapy with mitoxantrone plus prednisone for
symptomatic hormone-resistant prostate cancer: based on a Canadian randomized
trial with palliative end points. J Clin Oncol. 1998 Jun;16(6):2272-9. PubMed
PMID: 9626231.
§ Warde P,
O'Sullivan B, Bristow RG, Panzarella T,
Keane TJ, Gullane PJ, Witterick IP, Payne D, Liu FF, McLean M, Waldron J,
Cummings BJ. T1/T2 glottic cancer managed by external beam radiotherapy: the
influence of pretreatment hemoglobin on local control. Int J Radiat Oncol Biol
Phys. 1998 May 1;41(2):347-53. PubMed PMID: 9607350.
§ Tsang RW,
Brierley JD, Simpson WJ, Panzarella T,
Gospodarowicz MK, Sutcliffe SB. The effects of surgery, radioiodine, and
external radiation therapy on the clinical outcome of patients with
differentiated thyroid carcinoma. Cancer. 1998 Jan 15;82(2):375-88. PubMed
PMID: 9445196.
§ Warde P,
Gospodarowicz M, Panzarella T,
Catton C, Sturgeon J, Moore M, Jewett M. Management of stage II seminoma. J
Clin Oncol. 1998 Jan;16(1):290-4. PubMed PMID: 9440755.
§ Chow E,
Payne D, Keane T, Panzarella T,
Izard MA. Enhanced control by radiotherapy of cervical lymph node metastases
arising from nasopharyngeal carcinoma compared with nodal metastases from other
head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 1997 Aug
1;39(1):149-54. PubMed PMID: 9300749.
§
Brierley JD, Panzarella T, Tsang RW, Gospodarowicz MK, O'Sullivan B. A comparison
of different staging systems predictability of patient outcome. Thyroid
carcinoma as an example. Cancer. 1997 Jun 15;79(12):2414-23. Review. PubMed
PMID: 9191532.
§
Laperriere NJ, Cerezo L, Milosevic MF, Wong
CS, Patterson B,Panzarella T. Primary
lymphoma of brain: results of management of a modern cohort with radiation
therapy. Radiother Oncol. 1997 Jun;43(3):247-52. PubMed PMID: 9215783.
§
Warde P, Gospodarowicz MK, Banerjee D, Panzarella T, Sugar L, Catton CN, Sturgeon
JF, Moore M, Jewett MA. Prognostic factors for relapse in stage I testicular
seminoma treated with surveillance. J Urol. 1997 May;157(5):1705-9; discussion
1709-10. PubMed PMID: 9112510.
§
Couban S, Stewart AK, Loach D, Panzarella T, Meharchand J. Autologous
and allogeneic transplantation for multiple myeloma at a single centre. Bone
Marrow Transplant. 1997 Apr;19(8):783-9. PubMed PMID: 9134169.
§
McLean M, Panzarella
T, Warde PR, Gospodarowicz M, Duncan W, Catton C, Bissett R. Prostate
specific antigen levels during radical radiation therapy and the prediction of
outcome in localized carcinoma of the prostate. Clin Oncol (R Coll Radiol).
1997;9(4):226-33. PubMed PMID: 9315396.
§
Catton CN, Warde P, Gospodarowicz MK, Panzarella T, Catton P, McLean M, Milosevic
M. Transitional cell carcinoma of the renal pelvis and ureter: Outcome and
patterns of relapse in patients treated with postoperative radiation. Urol Oncol.
1996 Nov-Dec;2(6):171-6. PubMed PMID: 21224165.
§
Tsang RW, Brierley JD, Panzarella T, Gospodarowicz MK, Sutcliffe SB, Simpson WJ. Role of
radiation therapy in clinical hormonally-active pituitary adenomas. Radiother
Oncol. 1996 Oct;41(1):45-53. PubMed PMID: 8961367.
§
Brierley J, Tsang R, Simpson WJ, Gospodarowicz
M, Sutcliffe S, Panzarella T.
Medullary thyroid cancer: analyses of survival and prognostic factors and the role
of radiation therapy in local control. Thyroid. 1996 Aug;6(4):305-10. PubMed PMID:
8875751.
§
Samuels TH, Miller NA, Manchul LA, DeFreitas
G, Panzarella T. Squamous cell carcinoma
of the breast. Can Assoc Radiol J. 1996 Jun;47(3):177-82. PubMed PMID: 8640413.
§
Meakin JW, Hayward JL, Panzarella T, Allt WE, Beale FA, Bulbrook RD, Bush RS, Clark RM,
Fitzpatrick PJ, Hawkins NV, Jenkin RD, Pringle JF, Rider WD. Ovarian irradiation
and prednisone following surgery and radiotherapy for carcinoma of the breast.
Breast Cancer Res Treat. 1996;37(1):11-9. PubMed PMID: 8750523.
§
Timon CI, Dardick I, Panzarella T, Thomas J, Ellis G, Gullane P. Clinico-pathological
predictors of recurrence for acinic cell carcinoma. Clin Otolaryngol Allied
Sci. 1995 Oct;20(5):396-401. PubMed PMID: 8582068.
§
Warde P, Gospodarowicz MK, Panzarella T, Catton CN, Sturgeon JF,
Moore M, Goodman P, Jewett MA. Stage I testicular seminoma: results of adjuvant
irradiation and surveillance. J Clin Oncol. 1995 Sep;13(9):2255-62. PubMed
PMID: 7666083.
§
Catton CN, O'Sullivan B, Bell R, Cummings B,
Fornasier V, Panzarella T. Aggressive
fibromatosis: optimisation of local management with a retrospective failure
analysis. Radiother Oncol. 1995 Jan;34(1):17-22. PubMed PMID: 7792394.
§
Tsang RW, Brierley JD, Panzarella T, Gospodarowicz MK, Sutcliffe SB, Simpson WJ. Radiation
therapy for pituitary adenoma: treatment outcome and prognostic factors. Int J
Radiat Oncol Biol Phys. 1994 Oct 15;30(3):557-65. PubMed PMID: 7928486.
§
Timon CI, Dardick I, Panzarella T, Patterson B, Thomas MJ, Ellis GL, Gullane PJ. Acinic
cell carcinoma of salivary glands. Prognostic relevance of DNA flow cytometry
and nucleolar organizer regions. Arch Otolaryngol Head Neck Surg. 1994
Jul;120(7):727-33. PubMed PMID: 8018325.
§
Duncan W, Catton CN, Warde P, Gospodarowicz
MK, Munro AJ, Lakier R, Simm J, Panzarella
T. The influence of transurethral resection of prostate on prognosisof
patients with adenocarcinoma of the prostate treated by radical radiotherapy.
Radiother Oncol. 1994 Apr;31(1):41-50. PubMed PMID: 8041897.
§ Laroye GJ, Panzarella T. Two techniques for
measuring invasion in solid tumors. Evaluated in a retrospective study of 73
cases of breast carcinoma with 10-year follow-up. APMIS. 1994
Feb;102(2):103-11. PubMed PMID: 8167005.
§ Tsang RW,
Gospodarowicz MK, Sutcliffe SB, Sturgeon JF, Panzarella T, Patterson BJ. Non-Hodgkin's lymphoma of the thyroid
gland: prognostic factors and treatment outcome. The Princess Margaret Hospital
Lymphoma Group. Int J Radiat Oncol Biol Phys. 1993 Oct 20;27(3):599-604. PubMed
PMID: 8226154.
§ Tsang RW,
Laperriere NJ, Simpson WJ, Brierley J, Panzarella
T, Smyth HS. Glioma arising after radiation therapy for pituitary adenoma.
A report of four patients and estimation of risk. Cancer. 1993 Oct
1;72(7):2227-33. Erratum in: Cancer 1994 Jan 15;73(2):492. PubMed PMID:
8374881.
§ McLean M,
Akl AM, Warde P, Bissett R, Panzarella T,
Gospodarowicz M. The results of primary radiation therapy in the management of
squamous cell carcinoma of the penis. Int J Radiat Oncol Biol Phys. 1993 Mar
15;25(4):623-8. PubMed PMID: 8454480.
§ McLean M,
McGowan TS, Catton CN, Catton PA, Panzarella
T. The impact of prostatic manipulation upon serum PSA in patients with
adenocarcinoma of the prostate. Clin Oncol (R Coll Radiol). 1993;5(5):293-6.
PubMed PMID: 7508259.
§ Zemlickis
D, Lishner M, Degendorfer P, Panzarella
T, Burke B, Sutcliffe SB, Koren G. Maternal and fetal outcome after breast
cancer in pregnancy. Am J Obstet Gynecol. 1992 Mar;166(3):781-7. PubMed PMID:
1550143.
§ Zemlickis
D, Lishner M, Degendorfer P, Panzarella
T, Sutcliffe SB, Koren G. Fetal outcome after in utero exposure to cancer
chemotherapy. Arch Intern Med. 1992 Mar;152(3):573-6. PubMed PMID: 1546920.
§ Lishner M,
Zemlickis D, Degendorfer P, Panzarella T,
Sutcliffe SB, Koren G. Maternal and foetal outcome following Hodgkin's disease
in pregnancy. Br J Cancer. 1992 Jan;65(1):114-7. PubMed PMID: 1733434; PubMed
Central PMCID:
§ PMC1977347.
§ Zemlickis
D, Lishner M, Degendorfer P, Panzarella
T, Sutcliffe SB, Koren G. Maternal and fetal outcome after invasive
cervical cancer in pregnancy. J Clin Oncol. 1991 Nov;9(11):1956-61. PubMed
PMID: 1941053.
§ Lishner M,
Slingerland J, Barr J, Panzarella T,
Degendorfer P, Sutcliffe S. Second malignant neoplasms in patients with non-Hodgkin’s
lymphoma. Hematol Oncol. 1991 May-Jun;9(3):169-79. PubMed PMID: 1937408.
§ Jenkin D,
Doyle J, Berry M, Blanchette V, Chan H, Doherty M, Freedman M, Greenberg M, Panzarella T,
Saunders F, et al. Hodgkin's disease in children: treatment with MOPP and low-dose,
extended field irradiation without laparotomy. Late results and toxicity. Med
Pediatr Oncol. 1990;18(4):265-72. PubMed PMID: 2355885.
§ Tannock I,
Gospodarowicz M, Meakin W, Panzarella T,
Stewart L, Rider W. Treatment of metastatic prostatic cancer with low-dose
prednisone: evaluation of pain and quality of life as pragmatic indices of
response. J Clin Oncol. 1989 May;7(5):590-7. PubMed PMID: 2709088.
§ Biran H,
Feld R, Sagman U, Rusthoven J, Shepherd FA, Evans WK, Ginsberg RJ, Panzarella T, Malkin A.
Carcinoembryonic antigen, arginine vasopressin and calcitonin as markers of
early small-cell lung cancer relapse. Tumour Biol. 1989;10(5):258-67. PubMed
PMID: 2554479.
§ Simpson WJ,
Panzarella T, Carruthers JS,
Gospodarowicz MK, Sutcliffe SB. Papillary and follicular thyroid cancer: impact
of treatment in 1578 patients. Int J Radiat Oncol Biol Phys. 1988
Jun;14(6):1063-75. PubMed PMID: 2454902.
§ Goodwin PJ,
Panzarella T, Boyd NF. Weight gain
in women with localized breast cancer--a descriptive study. Breast Cancer Res
Treat. 1988 Apr;11(1):59-66. PubMed PMID: 3382763.
§ Simpson WJ,
McKinney SE, Carruthers JS, Gospodarowicz MK, Sutcliffe SB, Panzarella T. Papillary and follicular
thyroid cancer. Prognostic factors in 1,578 patients. Am J Med. 1987
Sep;83(3):479-88. PubMed PMID: 3661584.
§ Tannock I,
Payne D, Cummings B, Hewitt K, Panzarella
T. Sequential chemotherapy and radiation for nasopharyngeal cancer: absence
of long-term benefit despite a high rate of tumor response to chemotherapy. J
Clin Oncol. 1987 Apr;5(4):629-34. PubMed PMID: 35
§ Pang J; Panzarella T; Chow E. Prognosis and Survival Prediction. Journal of Alternative Medicine Research.
Vol. 3, Issue 3, 309-332
§ Panzarella
T. The value of a
collaborating biostatistician - Research for the Radiation Therapist: From
Question to Culture C. Gillian, L Di Prospero, N Harnett, L Holden, editors. CRC
Press 2014.
§ Comparing the effect of an inaccurate
control group event rate using fixed absolute and relative treatment
differences when re-estimating a sample size for a randomized clinical trial
with a dichotomous outcome. 32nd annual meeting of the International
Society for Clinical Biostatistics, August, 2011, Ottawa, Ont.
§
A Case for Using Absolute
Treatment Differences when Designing a Clinical Trial with a Dichotomous
Outcome. 32nd annual meeting of the Society of Clinical Trials, May
17, 2011, Vancouver BC.
§
Harmonizing the system of
research ethics review involving humans in Canada. 30th annual
meeting of the Society for Clinical Trials - Pre-Conference Workshop on Global
Harmonization of the Research Ethics Submission and Review process, May 3, 2009
Atlanta, Georgia
§ Cancer Registry and Data Access Committee
1998-present
§ Masters Admissions Committee, Division of
Biostatistics, University of Toronto 2008-present
§ Thesis Committee Member, Dr. Richard
Patrick, Candidate for MSc. in Clinical Epidemiology, University of Toronto.
The uptake of active surveillance for the management of prostate cancer in
Ontario: should we be doing more? Feb. 2014 – Sept. 2015
§ Ontario Cancer Research Ethics Board
2009-2015
§ Society for Clinical Trials Biostatistics
Membership Committee June 2009
§ Research Ethics Board (Oncology) 1998-2004
§ Clinical Research Unit Executive Committee
2003-2006
§ Program Committee SCT 2006
GRANT PANELS
§ Sep. 2017 – Canadian Cancer Society QOL
competition
§ Jun. 2012 – Cancer Research Society
§ Jun. 2011 – Cancer Research Society
§
Dranitsaris,
G. Statistical methods in clinical research: a review for pharmacists. J Oncol
Pharm Practice 4: 151-158, 1998.
§ Mason, W; Gentili, F; Macdonald, D; et al.
Clinical and radiographic stabilization in patients with recurrent or
unresectable meningiomas treated with hydroxyurea J. Neurosurg. 97:341-346, 2002.
§
Bujold
A, Massey CA, Kim JJ, Brierley J, Cho C, Wong RK, Dinniwell RE, Kassam Z,
Ringash J, Cummings B, Sykes J, Sherman M, Knox JJ, Dawson LA. Sequential Phase
I and II Trials of Stereotactic Body Radiotherapy for Locally Advanced Hepatocellular
Carcinoma. J Clin Oncol. 2013 May
1;31(13):1631-9.
Applied
Biostatistics Course. A 9-week course offered to clinical researchers seeking a
better understanding of the importance of statistics in medical research.
Introduction to
Biostatistics. A 4-session introduction featuring types of data, summarization
of data, probability distributions, sampling distributions, hypothesis tests,
p-values and reporting results. RT Therapists Nov-Dec. 2004.
Introduction to
Biostatistics. A 4-session introduction featuring types of data, summarization
of data, probability distributions, sampling distributions, hypothesis tests, p-values,
confidence intervals and common reporting errors. Clinical Research Unit staff
June 2005 and December 2005.
§ Invited Keynote address – “The misuse of
statistics is unethical” - 2016 U of T REB retreat, Hart House, University of
Toronto, Toronto, December 6, 2016
§ Integrity in Graduate Research Workshop –
Statistics 101 – Design, analysis and reporting concepts. University of
Toronto, March 18, 2016.
§ The Role of Biostatistics in a School of
Public Health, Dalla Lana School of Public Health Sept. 4, 2014
§ Guest Lecturer – Introduction to Research
Methods, Michener Institute, RMIP240, University of Toronto, Nov 19, 2013.
§ An Introduction to Statistics in Clinical
Trials for the Non-statistician. Celgene, Canada. Collingwood Ontario, August
28, 2013.
§ Statistical Analysis of Quantitative Data.
Advanced Practice Nurse Educator Research Seminar Series sponsored by
University Health Network’s Collaborative Academic Practice. Toronto, Ontario,
Dec. 14, 2012.
§ Data Integrity – A Statistician’s
Perspective. Clinical Trials Week, PMH, May 24 and June 15, 2012.
§ Preventing Missing Outcome Data in
Randomized Clinical Trials – CBMTG 0801 Data Coordinators Meeting - CBMTG 2012
Annual Meeting, Toronto, April 11, 2012.
§ Statistical Issues in Transplant Trials.
April 9, 2010. 12th Biennial CBMTG conference, Vancouver B.C.
§ Minimization and Statistics for CBMTG 0801.
Pre-conference Workshop. April 7, 2010. 12th Biennial CBMTG
conference, Vancouver B.C.
GRANTS
AWARDED (LAST 5 YEARS)
Title of Grant: Assessing Positive Margins at Radical Prostatectomy Using Real-Time
High Resolution Prostate-Specific Membrane Antigen-Based Gamma Imaging of the
Prostate Bed
Funding Opportunity: Movember Discovery Grant 2017
Source:
Prostate Cancer Canada
Grant #:
None provided yet
Dates of Proposed Project: Application deadline: April 3, 2017; Earliest start
date: July 2017
Dollars:
$197,482 over 2 years
Name of PI: Dr. Neil Fleshner, UHN, Toronto
List of Co-PIs: Drs. Stephan Probst, Tony Panzarella, Theodorus van der Kwast, Ravi
Mohan
The major goal of this project
is to evaluate the ability of transrectal prostate specific membrane antigen
(PSMA) imaging to guide surgery by detecting positive margins at radical
prostatectomy.
Title of the Grant:
The Canadian F.I.G.H.T. (Fluorescence Image-Guided Help in Treating) Breast
Cancer Surgical Trial
Source: CIHR
Dollars: $3,000,000.00
Dates: 2017 - 2022
Name of PI: Ralph DaCosta
List of Co-PIs: Wey-Liang Leong, Alexandra Easson, Susan Done,
David McCready, Gary Groot, Lucy Helyer, Claire Holloway, Murray Krahn,
Pamela Meiers, Daphne Mew, Cheryl Rosen, Jory Simpson, Paul Tenenbein
Goal: To reduce re-excision rate after breast conservative surgery in breast
cancer patients using fluorescence imaging of margins in situ. We will
specifically investigate i) if FL imaging during index surgery reduce
re-excision rates due to missed positive margins ii) the diagnostic
accuracy measures (sensitivity, specificity, TP, FP, TN, FN) of FL image-guided
surgery to detect positive margins iii) if surgery with fluorescence
image-guidance improve cosmesis and quality of life (QoL) by reducing the
amount of tissue removed.
CIHR Foundation Scheme: 2014 1st
Live Pilot: Development of a National Quality Improvement Program in
Postmastectomy Breast Reconstruction to Optimize Patient-Centred Experience. PI:
Toni Zhong CIHR $860,006 over
5 years.
Evaluation of Myocardial Changes during
Breast Adenocarcinoma therapy to detect Cardiotoxicity Earlier – The
EMBRACE-MRI study. PI: Paaladinesh Thavendiranathan, Co-PI Dr. Bernd
Wintersperger. CIHR. Aug 1, 2015. Total funding $898, 493.
GRANTS
AWARDED (LAST 5 YEARS)
CBCF; Pre-consultation Educational Group
Intervention to Improve Shared Decision Making for Postmastectomy Breast
Reconstruction; PI: Dr. Toni Zhong; CoI: Dr. Nancy Baxter, Dr. Brett Beber, Dr.
Terry Cheng, Dr. Jeffrey Hoch, Dr. Stefan Hofer, Dr. Wanrudee Isaranuwatchai,
Dr. Jennifer Jones, Dr. Kelly Metcalfe, Dr. Anne O'Neill, Mr. Tony Panzarella, Dr. Jennica Platt;
Total Requested Amount: $352,785; Funding duration: 3 years (2015-2018)
Fleshner N;
Joshua A; Alibhai S; Finelli A; Lipscombe L; Margel D; Panzarella T; Saad F; Sweet J. Randomized Double Blind Trial of
Metformin In Reducing Progression Among Men On Expectant Management For Low
Risk Prostate Cancer: The Mast (Metformin Active Surveillance Trial) Study.
Funds Requested: $1,250,000. Support
Period: 02/2013 – 01/2018 Canadian
Cancer Society Research Institute.
Novel Window of Opportunity Trial to
Evaluate the Impact of Statins to Oppose Prostate Cancer (Win-STOPca). Penn L, Fleshner N et al. OCI
Translational Collaborative Grant Competition. Total
budget $533,946. Members of OCI
Win-STOPca Collaborative Team: Linda Penn (Basic Science Co-lead; conducted
research on molecular mechanism of statins as anticancer agents for over 10
yrs), Neil Fleshner (Clinician/GU Surgeon Co-lead; conducted research showing
statin use is associated with decrease risk of prostate cancer (newest data
presently under review for publication) and also conducted several leading edge
clinical trials in prostate cancer, Rob Hamilton (newly hired GU Surgeon at PMH
who has conducted research and published several papers on statins and prostate
cancer), Rob Bristow (Clinician Scientist who has conducted extensive research
in prostate cancer, including newly developed molecular biomarkers based on DNA
copy number variation to distinguish intermediate and high-risk patients), Tony Panzarella (Clinical trials
statistics expert), Michael Roehrl (Head of UHN Biobank), Thio van der Kwast
(Pathologist specializing in prostate cancer), Karen Heaney (GU Clinical trials
coordinator), OCI Genomics Centre (Bioinformatics and genetics expertise).
Stephen Couban et
al. Improved Assignment to Best Available Therapy for Myelodysplasia/Acute Myeloid
Leukemia. Terry Fox Research Institute. $1,500,000
for Phase I (1-year 2012)
Irwin Ronald
Walker; Jean Roy; Tony Panzarella;
Ronan Foley; Kirk Schultz; Stephen Couban; Stephanie Lee; Paul Martin; Arlene
Nugent - A Randomized Trial of Thymoglobulin to Prevent Chronic Graft versus
Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplantation
from Unrelated Donors $1,200,000 CAN
(2009-0213). CIHR
GRANTS
AWARDED (LAST 5 YEARS)
Schultz, K (PI), S. Couban, C. Toze, T.
Panzarella, G. Devins et al. Transplantation
of G-CSF Stimulated Marrow vs. Blood NIH (NCI) $2,225,000 US over 5 years (2006-2011).