2015
Ahmed, S., Bott, D., Gomez, A., Tamblyn, L., Rasheed, A., Cho, T., MacPherson, L., Sugamori, K.S., Yang, Y., Grant, D.M., Cummins, C.L., and Matthews, J. (2015) Loss of the mono-ADP-ribosyltransferase, Tiparp, increases sensitivity to dioxin-induced steatohepatitis and lethality. J Biol Chem 290(27):16824 - 16840.
Bindesbøll, C., Fan, Q., Nørgaard, R.C., MacPherson, L., Ruan, H.B., Wu, J., Pedersen, T.Å., Steffensen, K.R., Yang, X., Matthews, J., Mandrup, S., Nebb, H.I., and Grønning-Wang, L.M. (2015) Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity. J Lipid Res 56(4): 771 - 785.
2014
Hecht, E., Zago, M., Sarill, M., Rico de Souza, A., Gomez, A., Matthews, J., Hamid, Q., Eidelman, D.H., and Baglole, C.J. (2014) Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation. Toxicol Appl Pharmacol 280(3):511 - 525.
MacPherson, L., Ahmed, S., Tamblyn, L., Krutmann, J., Förster, I., Weighardt, H., and Matthews, J. (2014) Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling. Int J Mol Sci. 15(5):7939 - 7957.
Ahmed, S., Wang, A., Celius, T., Matthews, J. (2014) Zinc finger nuclease-mediated knockout of AHR or ARNT in human breast cancer cells abolishes basal and ligand-dependent regulation of CYP1B1 and differentially affects estrogen receptor a transactivation. Toxicol Sci. 138(1): 89 - 103.
2013
Matthews, J. and Ahmed, S. (2013) AHR- and ER-Mediated Toxicology and Chemoprevention in Advances in Molecular Toxicology, Volume 7 (pp. 1 - 38). Elsevier. Amsterdam, The Netherlands.
Lo, R., and Matthews, J. (2013) The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 (NRF2) transactivation in MCF-7 breast cancer cells. Toxicol Appl Pharmacol. 270(2):139-148.
MacPherson, L., Tamblyn, L., Rajendra, S., Bralha, F., McPherson, J.P., and Matthews, J. (2013) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poly(ADP-ribose) polymerase (TiPARP) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acid Res. Feb 1;41(3):1604-21.
Wu, A., Dalvi, p., Lu, X., Yang, M., Riddick, D., Matthews, J., Clevenger, C.V., Ross, D.D., Harper, P., and Ito, S. (2013) Identification of a prolactin-responsive STAT5 binding element in the 5’-flanking region of the human BRCP/ABCG2 gene. Mol. Pharm.Feb;83(2):377-88.
2012
Lo, R and Matthews, J. (2012) High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol. Sci. 130(2):349-61.
Ahmed, S., Al-Saigh, Sarra and Matthews, J (2012) FOXA1 is essential for aryl hydrocarbon receptor-dependent regulation of cyclin G2. Mol. Can. Res. 10:636-48.
2011
Lo, R., Forgacs, A., Celius, T., MacPherson, L., Harper, P., Zacharewski, T., and Matthews, J. (2011) Genome-wide Analysis of Aryl Hydrocarbon Receptor Binding Targets in Dioxin-Treated Mouse Hepatic Tissue. Toxicol. Appl. Pharmacol. 257(1):38-47.
Dere, E., Lo, R., Celius, T. Matthews, J., and Zacharewski, T. (2011) Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver. BMC Genomics. 12(1):365.
Powis, M., Celius, T., and Matthews, J. (2011) Ligand-dependent coactivator recruitment and a role for Y322 in aryl hydrocarbon receptor-mediated transcription. Biochem Biophys Res Comm. 410(4):859-65.
2010
Celius, T and Matthews, J. (2010) Functional analysis of six aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines. Toxicology, 277, 59-65.
MacPherson. L. and Matthews, J. (2010) Inhibition of AHR-dependent transcription by resveratrol or kaempferol is independent of estrogen receptor alpha in T-47D human breast cancer cells. Cancer Lett., 299, 119-129.
Pansoy, A., Ahmed, S., Valen, E., Sandelin, A., and Matthews, J. (2010) 3-methylcholanthrene-induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol Sci 117, 90–100.
Celius, T., Pansoy, A., Matthews, J., Okey, A.B. Henderson, M., Krueger, S., and Williams, D. (2010) Induction of flavin-containing monooxygenase-3 (FMO3) mRNA by 3-methylcholanthrene and cycloheximide in mouse Hepa1c1c7 hepatoma cells. Toxicol Appl Pharmacol 247, 60-69.
Lo, R., Burgoon, L., MacPherson, L., Ahmed, S. and Matthews, J. (2010) Estrogen receptor and estrogen dependent regulation of CYP2B6 in human breast cancer cells. BBA Gen Regulatory Mechanisms. 1799, 469-479.
2009
Ahmed, S, Valen, E., Sandelin, A., and Matthews, J. (2009). Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters. Toxicol Sci 111, 254-266.
Wihlén, B., Ahmed, S., Inzunza, J., and Matthews, J. (2009) Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor transactivation. Mol Cancer Res 7, 977-986.
MacPherson, L., Lo, R., Ahmed, S, Pansoy, P., and Matthews, J. (2009) Activation Function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1. Biochem Biophys Res Comm 385, 263-268.
2008
Celius, T., Roblin, S., Harper, P.A., Boutros, P.C., Moffat, I.D., Wendelin, D., Matthews, J., Pohjanvirta, R., and Okey, A.B. (2008) Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver. Drug Metab Dispos 36, 2499-2505.
2007
Matthews, J., Wihlén, B., Heldring, N., Helguero, L., Macpherson, L., Treuter, E., Haldosén, L- A. and Gustafsson, J-Å. (2007) Coplanar 3,3’,4,4’,5-pentachlorinated biphenyl and non-coplanar 2,2’,4,6,6’-pentachlorinated biphenyl differentially induce recruitment of estrogen receptor a to aryl hydrocarbon receptor target genes. Biochem J 406, 343–353.
Zhao, C., Matthews, J., Tujague, M., Wan, J., Ström, A., Toresson, G., Lam, E., Cheng, G., Gustafsson, J- Å and Dahlman-Wright, K. (2007) Estrogen receptor ß2 negatively regulates the transactivation of estrogen receptor a in human breast cancer cells. Cancer Res 67, 3955-3962.
2006
Matthews, J., Wihlén, B., Ström, A., and Gustafsson, J-Å. (2006) ERß modulates ERa-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen responsive promoters. Mol Endocrinol 20, 534-543.
2005
Matthews, J., Almlöf, T, Kietz, S. Leers, Jörg, L., and Gustafsson, J-Å. (2005) Estrogen regulation of SOCS-3 in human breast cancer cells. Biochem Biophys Res Comm 335, 168-174.
Huang, Y-W., Matthews, J., Fertuck, K., and Zacharewski, T.R. (2005) Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Toxicol Appl Pharmacol 24, 2002-2009.
Matthews, J., Whilén, B., Thomsen, J., and Gustafsson, J-Å. (2005) Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor a to TCDD responsive promoters. Mol Cell Biol 25, 5317-5328.
Båvner, A., Matthews, J., Gustafsson, J-Å. and Treuter, E. (2005) A role of EID3 in tissue-specific coactivator antagonism. Nucl Acids Res 33, 3561-3569.
2004
Kietz, S., Thomsen, J.S., Matthews, J., Pettersson, K., Ström, A., and Gustafsson, J-Å. (2004) The AhR inhibits estrogen-induced estrogen receptor ß in breast cancer cells. Biochem Biophys Res Comm 320, 76-82.
Antonson, P., Al-Beidh, F., Matthews, J., and Gustafsson, J-Å (2004) RAP250 gene: genomic structure and promoter analysis. Gene 327, 233-238.
Sanyal, S., Matthews, J., Bouton, D., Choi, H-S., Treuter, E., and Gustafsson, J-Å. (2004) DNA-response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor- related receptor gamma (ERR?). Mol Endocrinol 18, 312-325.
2003
Brunnberg, S., Pettersson, K., Rydin, E., Matthews, J., Hanberg, A., and Pongratz, I. (2003) The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Proc Natl Acad Sci USA 100, 6517-6522.
2002
Matthews, J., Celius, C., Fertuk, K., Huang, Y-W., Fong, C., and Zacharewski, T.R. (2002) Ability of several natural and synthetic estrogenic chemicals to induce gene expression mediated by estrogen receptors from several vertebrate species. J Steroid Biochem Mol Bio 82, 181-194.
Rosen, G., O’Bryant, E., Matthews, J., Zacharewski, T.R., and Wade, J. (2002) Distribution of androgen receptor mRNA expression and immunoreactivity in the brain of the green anole lizard. J Neuroendocrinol 14, 19-28.
2001
Matthews, J., Clemons, J.H., and Zacharewski, T.R. (2001) Reciprocal mutagenesis between human a L349/M528 and rainbow trout M317/I496 estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures. Mol Cell Endocrinol 183, 127-139.
Fertuck, K.F., Kumar, S., Sikka, H.C., Matthews, J., and Zacharewski, T.R. (2001) Interaction of PAH-related compounds with the a and ß isoforms of the estrogen receptor. Toxicol Lett 121, 167-177.
Celius, T, Matthews, J., Giesy, J.P., and Zacharewski, T.R. (2001) Quantification of vitellogenin and zona radiata proteins from rainbow trout (Oncorhynchus mykiss) liver after in vivo treatment with a-zearalenol and estradiol-17ß using the TaqMan assay. J Steroid Biochem Mol Bio 75, 109-119.
Matthews, J., Twomey, K., and Zacharewski, T.R. (2001) Comparison of the interactions of bisphenol A and its metabolite bisphenol A glucuronide with estrogen receptors a and ß. Chem Res Toxicol 14, 149-157.
2000
Fertuck, K.F., Matthews, J., and Zacharewski, T.R. (2000) Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo. Toxicol Sci 59, 231-240.
Matthews, J., Celius, T., Halgren, R., and Zacharewski, T.R. (2000) Differential estrogen receptor binding of estrogenic substances: a species comparison. J Steroid Biochem Mol Biol 74, 223-234.
1999
Matthews, J., and Zacharewski, T.R. (1999) Differential binding affinities of PCBs, HO-PCBs and Aroclors with recombinant human, rainbow trout (Oncorhynchus mykiss) and reptilian (Anolis carolinensis) estrogen receptors using a semi-high throughput competitive binding assay. Toxicol Sci 53, 326-339.
1998
Zacharewski, T., Meek, M.D., Clemons, J.H., Wu, Z.F., Fielden, M.R. and Matthews, J. (1998) Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicol Sci 48, 282-293.
