lavoie lab
Molecular mechanisms of mitotic chromosome transmission

    Abnormal chromosome segregation in the form of trisomies occurs in 25% of aborted human fetuses and 0.3% of newborns.  In addition, aberrant chromosome transmission significantly enhances the progression of many cancers.  As such, the maintenance of genetic stability is a fundamental aspect of all cell proliferation.  

    My lab is interested in understanding the molecular mechanisms which govern faithful chromosome segregation during cell division, using budding yeast as a model organism. By combining genomic, biochemical and cell biological approaches in the budding yeast S. cerevisiae, we’ve gained new insight into how chromosomes are packaged and faithfully transmitted during the eukaryotic cell cycle.  

    My group's overall goal is to understand the multiple roles of the condensin complex in the transmission of genetic material in eukaryotic cells. Condensins affect multiple aspects of chromosome biology including sister chromatid cohesion, mitotic chromosome condensation, kinetochore function, DNA repair and transcriptional silencing,.  Their study provides a unique window on many fundamental aspects of chromosome metabolism during both interphase and mitosis.
PI:  Brigitte (Bri) Lavoie
Dept of Molecular Genetics
University of Toronto
Medical Sciences Bldg, #4278
1 King’s College Circle
Toronto Ontario CANAD
M5S 1A8
PH: 1-416-978-6123
FAX: 1-416-978-6885