Phage Canada

Molenda O, Tang S, Lomheim L, Gautam VK, Lemak S, Yakunin AF, Maxwell KL, Edwards EA. (2019) Extrachromosomal circular elements targeted by CRISPR-Cas in Dehalococcoides mccartyi are linked to mobilization of reductive dehalogenase genes. ISME J 13:24-38.

Maxwell KL. 2019. Phages Tune in to Host Cell Quorum Sensing. Cell 176:7-8.

Taylor VL, Fitzpatrick AD, Islam Z, Maxwell KL. 2019. The Diverse Impacts of Phage Morons on Bacterial Fitness and Virulence. Adv Virus Res 103:1-31.

Kronheim S, Daniel-Ivad M, Duan Z, Hwang S, Wong AI, Mantel I, Nodwell JR, Maxwell KL. (2018) A chemical defence against phage infection. Nature 564:283-286.

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Davidson AR, Maxwell KL. 2018. Type VI secretion system baseplate. Nat Microbiol 3:1330-1331.

Tsao YF, Taylor VL, Kala S, Bondy-Denomy J, Khan AN, Bona D, Cattoir V, Lory S, Davidson AR, Maxwell KL. (2018) Phage Morons Play an Important Role in Pseudomonas aeruginosa Phenotypes. J Bacteriol 200.

Stanley SY, Maxwell KL. 2018. Phage-Encoded Anti-CRISPR Defenses. Annu Rev Genet 52:445-464.

Pawluk A, Davidson AR, Maxwell KL. 2018. Anti-CRISPR: discovery, mechanism and function. Nat Rev Microbiol 16:12-17.

Pawluk A, Shah M, Mejdani M, Calmettes C, Moraes TF, Davidson AR, Maxwell KL. (2017) Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein. MBio 8.

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. (2017) A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell 170:1224-1233 e1215.

Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B. (2017) Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Cell 169:47-57 e11.

Maxwell KL. 2017. The Anti-CRISPR Story: A Battle for Survival. Mol Cell 68:8-14.

Pawluk A, Amrani N, Zhang Y, Garcia B, Hidalgo-Reyes Y, Lee J, Edraki A, Shah M, Sontheimer EJ, Maxwell KL, Davidson AR. (2016) Naturally Occurring Off-Switches for CRISPR-Cas9. Cell 167:1829-1838 e1829.

Bondy-Denomy J, Qian J, Westra ER, Buckling A, Guttman DS, Davidson AR, Maxwell KL. (2016) Prophages mediate defense against phage infection through diverse mechanisms. ISME J doi:10.1038/ismej.2016.79.

Maxwell KL, Garcia B, Bondy-Denomy J, Bona D, Hidalgo-Reyes Y, Davidson AR. (2016) The solution structure of an anti-CRISPR protein. Nat Commun 7:13134.

Nikkhoo N, Cumby N, Gulak PG, Maxwell KL. (2016) Rapid Bacterial Detection via an All-Electronic CMOS Biosensor. PLoS One 11:e0162438.

Buttner CR, Wu Y, Maxwell KL, Davidson AR. (2016) Baseplate assembly of phage Mu: Defining the conserved core components of contractile-tailed phages and related bacterial systems. PNAS U S A 113:10174-10179.

Maxwell KL. (2016) Phages Fight Back: Inactivation of the CRISPR-Cas Bacterial Immune System by Anti-CRISPR Proteins. PLoS Pathog 12:e1005282.

Pawluk A, Staals RH, Taylor C, Watson BN, Saha S, Fineran PC, Maxwell KL, Davidson AR. (2016) Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species. Nat Microbiol 1:16085.

Bondy-Denomy J, Garcia B, Strum S, Du M, Rollins MF, Hidalgo-Reyes Y, Wiedenheft B, Maxwell KL, Davidson AR. (2015) Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins. Nature 526:136-139.

Cumby N, Reimer K, Mengin-Lecreulx D, Davidson AR, Maxwell KL. (2015) The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of E. coli phage HK97. Mol Microbiol 96:437-447.

Kala S, Cumby N, Sadowski PD, Hyder BZ, Kanelis V, Davidson AR, Maxwell KL. (2014) HNH proteins are a widespread component of phage DNA packaging machines. PNAS 111:6022-6027.

Pawluk A, Bondy-Denomy J, Cheung VH, Maxwell KL, Davidson AR. (2014) A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa. MBio 5:e00896.

Bondy-Denomy J, Pawluk A, Maxwell KL, Davidson AR. 2013. Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system. Nature 493:429-432.

Maxwell KL, Fatehi Hassanabad M, Chang T, Paul VD, Pirani N, Bona D, Edwards AM, Davidson AR. 2013. Structural and functional studies of gpX of Escherichia coli phage P2 reveal a widespread role for LysM domains in the baseplates of contractile-tailed phages. J Bacteriol 195:5461-5468.

Pell LG, Cumby N, Clark TE, Tuite A, Battaile KP, Edwards AM, Chirgadze NY, Davidson AR, Maxwell KL. 2013. A conserved spiral structure for highly diverged phage tail assembly chaperones. J Mol Biol 425:2436-2449.

Tam W, Pell LG, Bona D, Tsai A, Dai XX, Edwards AM, Hendrix RW, Maxwell KL, Davidson AR. 2013. Tail tip proteins related to bacteriophage lambda gpL coordinate an iron-sulfur cluster. J Mol Biol 425:2450-2462.

Popovic A, Wu B, Arrowsmith CH, Edwards AM, Davidson AR, Maxwell KL. 2012. Structural and biochemical characterization of phage lambda FI protein (gpFI) reveals a novel mechanism of DNA packaging chaperone activity. J Biol Chem 287:32085-32095.

Cumby N, Edwards AM, Davidson AR, Maxwell KL. 2012. The bacteriophage HK97 gp15 moron element encodes a novel superinfection exclusion protein. J Bacteriol 194:5012-5019.

Moodley S, Maxwell KL, Kanelis V. 2012. The protein gp74 from the bacteriophage HK97 functions as a HNH endonuclease. Protein Sci 21:809-818.

Waller AS, Hug LA, Mo K, Radford DR, Maxwell KL, Edwards EA. 2012. Transcriptional analysis of a Dehalococcoides-containing microbial consortium reveals prophage activation. Appl Environ Microbiol 78:1178-1186.

Maxwell KL, Davidson AR. 2014. A shifty chaperone for phage tail assembly. J Mol Biol 426:1001-1003.

Cumby N, Davidson AR, Maxwell KL. 2012. The moron comes of age. Bacteriophage 2:225-228

the maxwell lab

Complete list of publications on PubMed.