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Ruogang Zhao

Postdoctoral Fellow (Johns Hopkins University)
PhD  (University of Toronto)
PhD study (University of Waterloo)
M.A.Sc (Carleton University)
B.Eng (Wuhan University)

 


Research Interests:

Biomedical Engineering

·  Characterization of biomechanics of cell-laden microtissues using novel bio-MEMS devices

·  Biomechanics and Mechanobiology of the heart valves

·  Mechano-regulation of embryogenesis and 3D tissue morphogenesis

Structural Mechanics

     ·  Experimental and computational characterization of the strength of steel hollow structural sections


Publications:

Journals:

12.    Zhao R., Boudou T., Wang W., Chen C. S., Reich D. H. 2012. The use of 3D microtissues integrated with magnetic cantilivers to simultaneously measure tissue mechanics and myofibroblastic differentiation during tissue maturation, ready for submission to Biomaterials

11.    Zhao R., Boudou T., Wang W., Chen C. S., Reich D. H. 2012. Decoupling cell and matrix mechanics in engineered microtissues using magnetically actuated microcantilevers, Advanced Materials, DOI: 10.1002/adma.201203585, impact factor: 13.9

10.    Zhao R., Mirzaei Z., Simmons C.A. 2012. The effects of cell contraction and loss of adhesion on apoptosis-related calcification of valve interstitial cells, ready for submission to PLOS ONE

9.    Zhao R., Simmons C. A. 2012. A simple method to estimate the exponential material parameters of heart valve tissue based on analogy between uniaxial tension and micropipette aspiration. Biomechanics and Modeling in Mechanobiology, DOI: 10.1007/s10237-013-0470-7, impact factor: 3.2

8.    Zhao R., Simmons C. A. 2012. An improved texture correlation algorithm to measure substrate–cytoskeletal network strain transfer under large compressive strain, Journal of Biomechanics, 45(1), pp 76-82, impact factor: 2.4

7.    Moraes C., Zhao R., Likhitpanichkul M., Simmons C. A., Sun Y. 2011. Semi-confined compression of microfabricated polymerized biomaterial constructs. Journal of Micromechanics and Microengineering, 21 054014, impact factor: 2.3

 

6.    Zhao R.*, Sider K.*, Simmons C. A., 2010. Measurement of layer-specific mechanical properties in multilayered biomaterials by micropipette aspiration. Acta Biomaterialia 7(3): 1120-1127 (* Equal contribution)

 

5.   B. Bhana, R. K. Iyer, W. L. K. Chen, R. Zhao, K. L. Sider, C. A. Simmons, M. Radisic 2009. Influence of Substrate Stiffness on the Phenotype of Heart Cells. Biotechnology & Bioengineering vol 105(6), pp 1148-1160

 

4.   Zhao R., Wyss K., Simmons. C.A. 2009. Comparison of analytical and inverse finite element approaches to estimate cell viscoelastic properties by micropipette aspiration. Journal of Biomechanics vol. 42, pp 2768-2773

 

3.   Yip, C.Y.Y., Chen, J.H., Zhao R., Simmons C.A. 2009. Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. Arteriosclerosis, Thrombosis, and Vascular Biology. 29, 936-942.

 

2.   Zhao, R., Huang, R.F., Khoo, H.A. and Cheng, J.J.R. 2009. Parametric finite element study on slotted rectangular and square HSS tension connections. Journal of Constructional Steel Research, vol. 65(3), pp 611-621.

 

1.    Zhao, R., Huang, R.F., Khoo, H.A and Cheng, J.J.R. 2008. Experimental study on slotted rectangular and square HSS tension connections.  Canadian Journal of Civil Engineering, 35(11): 1318–1330.

 

Conferences:

10.    Zhao R., Boudou T., Wang W-G., Chen C. S., Reich D. H. 2013. Integrated magnetic microdevice to probe the mechanobiology of engineered 3D microtissues, The 12th Joint Magnetism and Magnetic Materials (MMM)/Intermag Conference, Chicago, Illinois, USA

9.    Zhao R., Boudou T., Chen C. S., Reich D. H. 2012. Magnetic microtissue stretching system to study the mechanobiology of 3D fibroblast populated collagen matrix, Proceedings of the ASME 2012 Summer Bioengineering Conference, Puerto Rico

 

8.   Zhao R., Liu A. Boudou T., Chen C. S., Reich D. H. 2012. Measurements of the constituent contributions to the physical properties of fibroblast populated collagen microtissues with magnetic micro-tissue stretchers, American Physical Society March Meeting, Boston, USA

 

7.   Zhao R., Lin X., Simmons C. A., 2010 The Effects of Cell Contraction and Loss of Adhesion on the Apoptosis of Valve Interstitial Cells, Proceedings of the ASME 2010 Summer Bioengineering Conference, June 16-19, Naples Florida, USA

 

6.   Zhao R., Sider K. L., Simmons C. A., 2010 Comparison of Analytical and Finite Element Implementation of Exponential Constitutive Models for Valve Tissue Under Micropipette Aspiration, Proceedings of the ASME 2010 Summer Bioengineering Conference, June 16-19, Naples Florida, USA (podium presentation)

 

5.   Sider K., Zhao R., Yip, C.Y.Y., Simmons C. A., 2010. Local Valve Matrix Stiffness and Its Effect on Valve Interstitial Cell Differentiation. 4th Biennial Heart Valve Biology and Tissue Engineering meeting, Hilton Head Island, South Carolina

 

4.   Sider K., Zhao R., Simmons C. A., 2009. Single Layer Mechanical Property Measurement in Multilayer Biomaterials with Micropipette Aspiration. Proceedings of the BMES Fall Scientific Meeting, Pittsburgh, USA

 

3.   Zhao, R., Simmons C.A., 2009. Intracellular Strain and Mechanotransduction in Valve Interstitial Cells under Tension Release. Proceedings of the BMES Fall Scientific Meeting, Pittsburgh, USA

 

2.   Zhao, R., Wyss, K., Simmons. C.A. 2008. Comparison of three material models to predict the time-dependent deformation of a single cell under micropipette aspiration. Proceedings of the ASME 2008 Summer Bioengineering Conference, June 25-29, Marco Island, Florida, USA (podium presentation)

 

1.   Huang, R.F., Zhao, R., Khoo, H.A. and Cheng, J.J.R.  2006.  Strength of Slotted Rectangular and Square HSS Tension Connections.  Proceedings of the 11th International Symposium and IIW International Conference on Tubular Structures.  Quebec City, Quebec, Aug 31 to Sep 2, pp. 253-260.


 

Awards:

2010         Best poster presentation, MIE research symposium, U of Toronto

2009 – 2011 Heart and Stroke Foundation of Canada Doctoral Research Award

2009 – 2010 Ontario Graduate Scholarship (declined)

2007 – 2008 Barbara and Frank Milligan Graduate Fellowships, U of T

2006 – 2008 University of Toronto Open Fellowship

2006 – 2006 University of Waterloo Graduate Study Scholarship

2003 – 2005 Carleton University Departmental Scholarship

Teaching Experience:

Engineering Mechanics, Behaviour and Design of Steel Structures,

Engineering Concepts and Practices.

 

Industrial Experience:

Structural engineer (BASF-YPC Company Ltd.site), Shaw Stone &Webster Asia. Inc. (2002 ~ 2003)

Structural engineer , HQCEC (1999 ~ 2003)

 

Industrial Experience

Photo Album (links to Flicker)


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