News

Selected Publications

Li, P, Zhuo, M (1998). Silent glutamatergic synapses and nociception in mammalian spinal cord. Nature, 393:695-698.

Li, P, Wilding, TJ, Kim, SJ, Calejesan, AA, Huettner, JE, Zhuo, M (1999). Kainate receptor-mediated sensory synaptic transmission in mammalian spinal cord. Nature, 1999, 397:161-164.

Tang, YP, Shimizu, E., Dube, G., Rampon, C., Kerchner, G.A., Zhuo, M., Liu, G. and Tsien, J.Z (1999). Genetic enhancement of learning and memory in mice. Nature, 401:63-69.

Li, P, Kerchner, G.A., Sala, C., Wei, F., Huettner, JE, Sheng, M. and Zhuo, M (1999). AMPA receptor-PDZ protein interaction mediate synaptic plasticity in spinal cord. Nature Neuroscience, 1999, 2:972-977.

Wei, F., Li, P. and Zhuo, M (1999). Loss of synaptic depression in mammalian anterior cingulate cortex following amputation. Journal of Neuroscience, 19:9346-9354.

Zhuo, M., Holtaman, D.M., Li, Y., Demaro, J., Jacquin, M. and Bu, G (2000). Role of tissue-type plasminogen activator receptor LRP in hippocampal long-term potentiation. Journal of Neuroscience, 20:542-549.

Wei, F., Xu, Z.C., Qu, Z., Milbrandt, J. and Zhuo M (2000). Role of Egr1 in hippocampal synaptic enhancement induced by tetanic stimulation and amputation. Journal of Cell Biology, 149:1325-1333.

Wei, F., Wang, G.-D., Kerchner, G.A., Kim, S.J., Xu, H.-M., Chen, Z.-F. and Zhuo, M (2001). Genetic enhancement of persistent pain by forebrain NR2B overexpression. Nature Neuroscience, 4:164-169.

Wei, F. and Zhuo, M (2001). Potentiation of synaptic responses in the anterior cingulate cortex following digital amputation in rat. Journal of Physiology (Lond), 532:823-833.

Kerchner, G.A., Wang, G.D. and Qiu, C.-S., Huettner, J.E. and Zhuo, M (2001). Direct presynaptic regulation of GABA/Glycine release by kainate receptors in the dorsal horn: an ionotropic mechanism. Neuron, 32:477-488.

Wei F, Qiu CS, Liauw J, Robinson DA, Ho N, Chatila T, Zhuo M (2002). Calcium calmodulin-dependent protein kinase IV is required for fear memory. Nature Neuroscience, 5:573-579.

Wei F, Qiu CS, Kim SJ, Muglia L, Maas JW, Pineda VV, Xu HM, Chen ZF, Storm DR, Muglia LJ, Zhuo M. (2002). Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Neuron, 36:713-726.

Wei F, Xia XM, Tang J, Ao H, Ko S, Liauw J, Qiu CS, Zhuo M. (2003). Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents. Journal of Neuroscience 23:8402-8409.

Ko, S., Zhao, M-G., Toyoda, H., Qiu, C.S. and Zhuo, M. (2005). Altered behavioral responses to noxious stimuli and fear in GluR5- or GluR6 deficient mice. Journal of Neuroscience, 25:977-984.

Tang, J., Ko, S., Ding, H.K., Qiu, C.-S., Calejesan, A.A. and Zhuo, M. (2005) Pavlovian fear memory induced by activation in the anterior cingulate cortex. Molecular Pain 1:6.

Zhao MG, Toyoda H, Lee Y.-S., We LJ, Ko SW, Zhang XH, Jia Y.H., Shum F, Xu H, Li B-M, Kaang B.-K. and Zhuo M. (2005) Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contexual fear memory. Neuron, 47:1-14.

Zhao, M. G., Ko, S. W., Wu, L. J., Toyoda, H., Xu, H., Quan, J., Li, J., Jia, Y., Ren, M., Xu, Z. C., and Zhuo, M. (2006). Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain. Journal of Neuroscience 26, 8923-8930.

Wu, L. J., Ko, S. W., Toyoda, H., Zhao, M. G., Xu, H., Vadakkan, K. I., Ren, M., Knifed, E., Shum, F., Quan, J., et al. (2007). Increased Anxiety-Like Behavior and Enhanced Synaptic Efficacy in the Amygdala of GluR5 Knockout Mice. PLoS ONE 2, e167.

Wu LJ, Ren M, Wang H, Kim SS, Cao X, Zhuo M. (2008) Neurabin contributes to hippocampal long-term potentiation and contextual fear memory. PLoS ONE. 3:e1407.

Zhuo, M. (2008) Cortical plasticity and chronic pain. TINS 31:199-207.

Recent publications (2006-present)

Wei F, Vadakkan KI, Toyoda H, Wu LJ, Zhao MG, Xu H, Shum FW, Jia YH, Zhuo M (2006) Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice. J Neuroscience 26:851-861.

Vadakkan KI, Wang H, Ko SW, Zastepa E, Petrovic MJ, Sluka KA, Zhuo M. (2006) Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases. Mol Pain. 2:7.

Ao, H., Ko, S. and Zhauo, M. (2006) CREB activity maintains the survival of cingulate cortical pyramidal neurons in the adult mouse brain. Mol Pain. 2:15.

Blaeser, F., Sanders, M. J., Truong, N., Ko, S., Wu, L. J., Wozniak, D. F., Fanselow, M. S., Zhuo, M., and Chatila, T. A. (2006). Long-term memory deficits in Pavlovian fear conditioning in Ca2+/calmodulin kinase kinase alpha-deficient mice. Mol Cell Biol 26, 9105-9115.

Ko, S. W., Jia, Y., Xu, H., Yim, S. J., Jang, D. H., Lee, Y. S., Zhao, M. G., Toyoda, H., Wu, L. J., Chatila, T., et al. (2006). Evidence for a role of CaMKIV in the development of opioid analgesic tolerance. Eur J Neurosci 23, 2158-2168.

Steenland, H. W., Ko, S. W., Wu, L. J., and Zhuo, M. (2006). Hot receptors in the brain. Mol Pain 2, 34. (Review)

Toyoda, H., Zhao, M. G., and Zhuo, M. (2006). NMDA receptor-dependent long-term depression in the anterior cingulate cortex. Rev Neurosci 17, 403-413. (Review)

Vadakkan, K. I., Wang, H., Ko, S. W., Zastepa, E., Petrovic, M. J., Sluka, K. A., and Zhuo, M. (2006). Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases. Mol Pain 2, 7.

Wang, G. D., and Zhuo, M. (2006). Forebrain NMDA receptors contribute to neuronal spike responses in adult mice. Sheng Li Xue Bao 58, 511-520.

Wei, F., Wang, G. D., Zhang, C., Shokat, K. M., Wang, H., Tsien, J. Z., Liauw, J., and Zhuo, M. (2006). Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia. Mol Pain 2, 21.

Xu, H., Wu, L. J., Zhao, M. G., Toyoda, H., Vadakkan, K. I., Jia, Y., Pinaud, R., and Zhuo, M. (2006). Presynaptic regulation of the inhibitory transmission by GluR5-containing kainate receptors in spinal substantia gelatinosa. Mol Pain 2, 29.

Zeng, H., Gragerov, A., Hohmann, J. G., Pavlova, M. N., Schimpf, B. A., Xu, H., Wu, L. J., Toyoda, H., Zhao, M. G., Rohde, A. D., et al. (2006). Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding. Mol Cell Biol 26, 9352-9363.

Zhuo, M. (2006). Molecular mechanisms of pain in the anterior cingulate cortex. J Neurosci Res 84, 927-933.

Gu, J., and Zhuo, M. (2007). Editorial: Progress and Future of Molecular Pain. Mol Pain. 3, 2. (Editorial)

Shum, F. W., Wu, L. J., Zhao, M. G., Toyoda, H., Xu, H., Ren, M., Pinaud, R., Ko, S. W., Lee, Y. S., Kaang, B. K., and Zhuo, M. (2007). Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learn Mem 14, 304-312.

Toyoda, H., Wu, L. J., Zhao, M. G., Xu, H., Jia, Z., and Zhuo, M. (2007). Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex. J Cell Physiol 211, 336-343.

Toyoda, H., Wu, L. J., Zhao, M. G., Xu, H., and Zhuo, M. (2007). Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation. Dev Neurobiol 67, 498-509.

Vadakkan, K. I., Jia, Y. H., and Zhuo, M. (2007). Neuropathic pain models. Drug Discov Today. 3, 413-417. (Review).

Wang, H., Gong, B., Vadakkan, K. I., Toyoda, H., Kaang, B. K., and Zhuo, M. (2007). Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors. J Biol Chem 282, 1507-1517.

Wu, L. J., Ko, S. W., and Zhuo, M. (2007). Kainate receptors and pain: from dorsal root ganglion to the anterior cingulate cortex. Curr Pharm Des 13, 1597-1605. (Review)

Wu, L. J., Vadakkan, K. I., and Zhuo, M. (2007). ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia 55, 810-821.

Wu, L. J., Xu, H., Ren, M., Cao, X., and Zhuo, M. (2007). Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex. Mol Pain 3, 11.

Wu, L. J., Xu, H., Ren, M., and Zhuo, M. (2007). Genetic and pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice. Dev Neurobiol 67, 146-157.

Wu, L. J., and Zhuo, M., (2007). Supraspinal electrophysiological models for studying chronic pain. Drug Discov Today. 3, 405-411. (Review).

Zhuo, M. (2007). Neuronal mechanism for neuropathic pain. Mol Pain 3, 14.

Zhuo, M. (2007). Pain Editorial. Drug Discov Today. 3, 403-404. (Editorial).

Zhuo, M. (2007). Long-term potentiation in the anterior cingulate cortex. Mol Cell. 23:259-71 (Review).

Gong B, Wang H, Gu S, Heximer SP, Zhuo M. (2007) Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons. Eur J Neurosci 26:275-88.

Toyoda, H., Zhao, M.G., Wu, L.J, Ren, M., Zhuo, M. (2007) Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex. Molecular Pain 2007, 3:36.

Zhuo, M and Gu, J. (2008) Hit a new high. Molecular Pain. 4:4.

Du J, Creson TK, Wu LJ, Ren M, Gray NA, Falke C, Wei Y, Wang Y, Blumenthal R, Machado-Vieira R, Yuan P, Chen G, Zhuo M, Manji HK. (2008). The Role of Hippocampal GluR1 and GluR2 Receptors in Manic-like Behavior. J Neuroscience, 28:68-79.

Wu LJ, Ren M, Wang H, Kim SS, Cao X, Zhuo M. (2008) Neurabin contributes to hippocampal long-term potentiation and contextual fear memory. PLoS ONE. 3:e1407.

Steenland HW, Kim SS, Zhuo M. (2008). GluR3 subunit regulates sleep, breathing and seizure generation. European J Neuroscience. 27:1166-1173.

Zhuo, M. (2008) Cortical plasticity and chronic pain. TINS 31:199-207.

Wu, LJ, Kim, S and Zhuo, M.(2008) Molecular mechanisms of anxiety. Neurochemical Research, in press.

Wu LJ, Zhuo M. (2008). Resting Microglial Motility is Independent of Synaptic Plasticity in Mammalian Brain. J Neurophysiology, 99:2026-2032.

Wang et al (2008). FMRP regulation by mGluR1. J Neuroscience, in press.

Wu et al. (2008). CaMKIV overexpression and trace memory. Eur J Neuroscience, in press.