Davidson Lab


Stanley, SY, Borges, AL, K Chen. K-H, Swaney, DL, Krogan, NJ, Bondy-Denomy, J, and Davidson,      AR (2019). Anti-CRISPR Associated Proteins are Crucial Repressors of Anti-CRISPR Transcription. Cell 178, 1452-1464.

North OI, Sakai K, Yamashita E, Nakagawa A, Iwazaki T, Büttner C, Takeda S*, Davidson AR* (2019). Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres. Nature Microbiology, in press. *Co-Corresponding authors

Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington LB, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna JA, Davidson AR, Moraes TF, Wang Y, and Maxwell KL (2019). Inactivation of the CRISPR-Cas9 ribonucleoprotein complex by AcrIIC2. Nature Communications 10, 2806


Bondy-Denomy J, Davidson AR, Doudna JA, Fineran PC, Maxwell KL, Moineau S,Peng X, Sontheimer EJ, Wiedenheft B. A. (2018). Unified Resource for Tracking Anti-CRISPR Names. CRISPR J 1, 304-305.

Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ (2018). Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. mBio 9, e02321-18.

Tsao, Y.-F., Taylor, V.L., Kala, S., Bondy-Denomy, J., Khan, A.N., Bona, D., Cattoir, V., Lory, S., Davidson, A.R., and Maxwell, K.L. (2018). Phage morons play important roles in controlling Pseudomonas aeruginosa phenotypes. J Bacteriol. 200, e00189-18.


Pawluk, A., Shah, M., Mejdani, M., Calmettes, C., Moraes, T.F., Davidson, A.R., and Maxwell, K.L. (2017). Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein. mBio 8, e01751-17.

Harvey H, Bondy-Denomy J, Marquis H, Sztanko KM, Davidson AR*, and Burrows LL* (2017) Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation. Nature Microbiology 3, 47-52. *Co-Corresponding authors

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, and Doudna JA (2017) A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell 170, 1224-1233.

Chowdhury, S, Carter, J, Rollins, M.F., Golden, S.M., Jackson, R.N., Hoffmann, C., Nosaka, L., Bondy-Denomy, J., Maxwell, K.L., Davidson, A.R., Fischer, E.R., Lander, G.C., Wiedenheft, B. (2017) Structure reveals mechanmisms of viral suppressors that intercept a CRISPR RNA-guided surveillance complex. Cell 169, 47-57.


Pawluk, A, Amrani, N, Zhang, Y, Garcia, B, Hidalgo-Reyes, Y, Lee, J, Edraki, A, Shah, M, Sontheimer, E.J., Maxwell K.L., Davidson A.R. (2016) Naturally occurring off-switches for CRISPR-Cas9. Cell 167, 1829-1838.

Maxwell, K.L., Garcia, B., Bondy-Denomy, J., Bona, D., Hidalgo-Reyes, Y., Davidson, A.R. (2016). The solution structure of an anti-CRISPR protein. Nature Communications 7, 13134.

Büttner CR, Wu Y, Maxwell KL, Davidson AR. Baseplate assembly of phage Mu: Defining the conserved core components of contractile-tailed phages and related bacterial systems (2016). Proc Natl Acad Sci U S A 113, 10174-10179.

Pawluk A, Staals RHJ, Taylor C, Watson BNJ, Saha S, Fineran PC, Maxwell KL, and Davidson AR (2016). Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species. Nature Microbiology 1, 16085.

Bondy-Denomy J, Qian J, Westra ER, Buckling A, Guttman DS, Davidson AR*, and Maxwell KL* (2016). Prophages mediate defense against phage infection through diverse mechanisms. ISME Journal 10, 2854-2866. *co-corresponding authors


Vorontsova D, Datsenko KA, Medvedeva S, Bondy-Denomy J, Savitskaya EE, Pougach K, Logacheva M, Wiedenheft B, Davidson AR, Severinov K, Semenova E. (2015) Foreign DNA acquisition by the I-F CRISPR-Cas system requires all components of the interference machinery. Nucleic Acids Res. 43, 10848-10860.

Bondy-Denomy, J, Garcia, B, Strum, S, Du, M, Rollins, M, Hidalgo-Reyes, Y, Wiedenheft, B., Maxwell, KL., Davidson, AR. (2015) Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins. Nature 526, 136-139.

Cumby N, Reimer K, Mengin-Lecreulx D, Davidson AR, Maxwell KL. (2015) The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of E.coli phage HK97. Mol Microbiol. 96, 437-447.

Lam MH, Snider J, Rehal M, Wong V, Aboualizadeh F, Drecun L, Wong O, Jubran B, Li M, Ali M, Jessulat M, Deineko V, Miller R, Lee Me, Park HO, Davidson A, Babu M, Stagljar I. (2015) A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae. J Mol Biol. 427, 2088-2103.

Westra ER, van Houte S, Oyesiku-Blakemore S, Makin B, Broniewski JM, Best A, Bondy-Denomy J, Davidson A, Boots M, Buckling A. (2015) Parasite Exposure Drives Selective Evolution of Constitutive versus Inducible Defense. Curr Biol.  25, 1043-1049.


Pawluk A, Bondy-Denomy J, Cheung VH, Maxwell KL, Davidson AR. (2014) A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa. mBio 25, e00896.

Kala S, Cumby N, Sadowski PD, Hyder BZ, Kanelis V, Davidson AR, Maxwell KL. (2014). HNH proteins are a widespread component of phage DNA packaging machines. Proc Natl Acad Sci U S A 111, 6022-6027.

Zivanovic Y, Confalonieri F, Ponchon L, Lurz R, Chami M, Flayhan A, Renouard M, Huet A, Decottignies P, Davidson AR, Breyton C, Boulanger P.  (2014). Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein components. J Virol. 88, 1162-1174.


Maxwell KL, Fatehi Hassanabad M, Chang T, Paul VD, Pirani N, Bona D, Edwards AM, Davidson AR. (2013) Structural and functional studies of gpX of Escherichia coli phage P2 reveal a widespread role for LysM domains in the baseplates of contractile-tailed phages. J Bacteriol. 195, 5461-5468.

Tam, W., Pell, L.G., Bona, D., Tsai, A., Dai, X.X., Hendrix, R.W., Maxwell, K.L., and Davidson, A.R. (2013). Tail tip proteins related to bacteriophage lambda gpL coordinate an iron-sulphur cluster. J. Mol. Biol. 425, 2450–2462.

Pell, L.G., Cumby, N., Tuite, A., Bona, D., Edwards, A.M., Chirgadze, N., Davidson, A.R., and Maxwell, K.L. (2013). The X-ray crystal structure of gp13 from phage HK97 provides insight into the mechanism of action and evolution of tail assembly chaperone proteins. J. Mol. Biol. 425, 2436-2449.

Bondy-Denomy, J., Pawluk, A., Maxwell, K.L. & Davidson, A.R. (2013). Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system. Nature 493, 429–432.

Research Papers

A complete list of Davidson Lab Publications can be found at Pubmed.

Davidson Lab publications with citations can be viewed at Google Scholar.

Publications below are from 2013 to present.