De La Cruz-Herrera CF, Tatham MH, Siddiqi UZ, Shire K, Marcon E, Greenblatt JF, Hay RT, Frappier L. Changes in SUMO-modified proteins in Epstein-Barr virus infection identifies reciprocal regulation of TRIM24/28/33 complexes and the lytic switch BZLF1. PLoS Pathog. 2023 Jul 6;19(7):e1011477

Yockteng Melgar, J, Shire, K, Cheng, A.Z., Malik-Soni, N,. Harris, R.S. and Frappier, L. 2022 G1/S Cell Cycle Induction by Epstein-Barr Virus BORF2 is Mediated by P53 and APOBEC3B. Journal of Virology Sep 7;e0066022

Airo, A.M., Felix Lopez, A., Mancinelli, V., Evseev, D, Lopez-Orozco, J., Paszkowski, P., Shire, K., Frappier, L., Magor, K.E., Hobman, T.C. 2022 RNA-sequencing of ZIKV capsid expressing cells reveals novel insights into capsid-mediated subversion of host innate immune responses. Viruses 5;14(5):968.

Campbell, A.M., De La Cruz Herrera, C.F., Marcon, E., Greenblatt, J. and Frappier, L. 2022 Epstein-Barr Virus BGLF2 Commandeers RISC to Interfere with Cellular miRNA Function. PLoS Path. 18(1):e1010235.

Shire, K, Marcon, E., Greenblatt, J. and Frappier, L. 2021 Characterization of a Cancer-Associated Epstein-Barr Virus EBNA1 Variant Reveals a Novel Interaction with PLOD1 and PLOD3. Virology 562:103-109.

Cheng, A., Nóbrega de Moraes, S., Attarian, C., Yockteng-Melgar, J., Jarvis, M., Biolatti, M., Galitska, G., Dell'Oste, V.,i Frappier, L., Bierle, C., Rice, S., and Harris, R. 2019 A Conserved Mechanism of APOBEC Counteraction by Herpesviruses Ribonucleotide Reductase Large Subunits. J. Virol. 93(23), e01539-19

Salamun, S.G., Sitz, J., De La Cruz-Herrera, J.Yockteng Melgar, C.F., Marcon, E., Greenblatt, J., Fradet-Turcotte, A. and Frappier, L. 2019 The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD. J. Virol. 93(22), e01070-19

Siddiqi, U.Z., Vaidya, A., Li, X., Marcon, E., Tsao, W.S., Greenblatt, J. and Frappier, L. 2019 Identification of ARKL1 as a Jun-interacting Factor that Negatively Regulates EBV Reactivation. J. Virol. 93(20). pii: e00989-19.

Salamun, S.G., Sitz, J., De La Cruz-Herrera, C.F., Marcon, E., Greenblatt, J., Fradet-Turcotte, A. and Frappier, L. 2019 The Epstein-Barr Virus BMRF1 Protein Activates Transcription and Inhibits the DNA Damage Response by Binding NuRD. J. Virol. In press.

Siddiqi, U.Z., Vaidya, A., Li, X., Marcon, E., Tsao, W.S., Greenblatt, J. and Frappier, L. 2019 Identification of ARKL1 as a Jun-interacting Factor that Negatively Regulates EBV Reactivation. In press.

Georges, A., Coyaud, E., Marcon, E. Greenblatt, J., Raught, B. and Frappier, L. 2019 USP7 Regulates Cytokinesis through FBXO38 and KIF20B Scientific Reports. 9(1):2724.

Georges, A., Marcon, E. Greenblatt, J. and Frappier, L. 2018 Identification and Characterization of USP7 Targets in Cancer Cells. Scientific Reports. 8(1):15833.

Cheng, A.Z. +, Yockteng-Melgar, J. +, Jarvis, M.C., Malik-Soni, N., Borozan, I., Carpenter, M.A., McCann, J.L., Shaban, N.M., Marcon, E., Greenblatt, J., Brown, W.L., Frappier, L.* and Harris, R.S.* 2019 Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity. Nature Microbiology, 4(1):78-88. +co-first authors, *co-senior authors

De La Cruz-Herrera, C.F., Shire, K., Siddiqi, U.Z. and Frappier, L. 2018 A Genome-wide Screen of Epstein-Barr Virus Proteins that Modulate Host SUMOylation Identifies a SUMO E3 Ligase conserved in Herpesviruses. PLoS Pathogens. 17(4), e1007176. PMID:29979787

Ho,T-H., Sitz, J., Shen, Q., Leblanc-Lacroix, A., Campos, E. I., Borozan, I., Marcon, E., Greenblatt, J., Fradet-Turcotte, A., Jin, D-Y. and Frappier, L. 2018 A Screen for Epstein-Barr Virus Proteins that Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein. J. Virol. JVI.00262-18. PMID: 29743367

Airo, A.M., Urbanowski, M.D., Lopez-Orozco, J, You, J.H., Skene-Arnold, T.D., Yamshchikov, V., Holmes, C., Malik-Soni, N., Frappier, L. and Hobman, T.C. 2018 Expression of Flavivirus capsids enhance the cellular environment for viral replication by activating Akt-signalling pathways. Virology. 516, 147-157. PMID: 29358114

Borozan, I., Zapatka, M., Frappier, L.,* and Ferretti, V.* 2018 Analysis of Epstein-Barr Virus Genomes and Expression Profiles in Gastric Adenocarcinoma. J. Virology. 92, e01239-17. PMID: 29093097. * co-senior authors

Shire, K., Wong, A.I., Tatham, M.H., Anderson, O.F., Ripsman D., Gulstene, S., Moffat, J. Hay, R.T. and Frappier, L. 2016 Identification of RNF168 as a PML Nuclear Body Regulator. J. Cell Sci. 129, 580-591.

Jae You, Shangmei Hou, Natasha Malik-Soni, Zaikun Xu, Anil Kumar, Richard Rachubinski, Lori Frappier and Tom Hobman 2015 Flavivirus infection impairs peroxisome biogenesis and early anti-viral signaling. J. Virol. 89(24):12349-61.

Marcon, E., Jain, H., Bhattacharya, A., Guo, H., Phanse, S., Pu, S., Byram, G., Collins, B.C., Dowdell, E., Fenner, M., Guo, X., Hutchinson, A., Kennedy, J.J., Krastins, B., Larsen, B., Lin, Z-Y., Lopez, MF., Loppnau, P., Miersch, S., Nguyen, T., Olsen, J., Phanse, S., Ravichandran, M., Seitova, A., Vadali, G., Vogelsang, L.,Whiteaker, J.R., Zhong, G., Zhong, N., Zhao. L., Aebersold, R., Arrowsmith, C.H., Emili, A., Frappier, L., Gingras, A-C, Gstaiger, M., Paulovich, A.G., Koide, S., Kossiakoff, T., Sidhu, S.S., Wodak, S.J., Graslund, S., Greenblatt, J.F., Edwards, A.M. 2015 Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation. Nature Methods. 12(8), 725-731.

Pfoh, R., Lacdao, I.,Georges, A., Capar, A., Zheng, H., Frappier, L., and Saridakis, V. 2015 Crystal structure of the USP7-ICP0 complex reveals a novel mechanism used by viral and cellular proteins to target USP7. PLoS Pathogens. 11(6): e1004950.

Mansouri, S., Pan, Q., Blencowe, B., Claycomb, J. and Frappier, L. 2014 The Epstein-Barr Virus EBNA1 Protein Regulates Viral latency Through Effects on Let-7 microRNA and Dicer. J. Virol. 88, 11166-11177.

Paladino, P., Marcon, E., Greenblatt, J. and Frappier, L. 2014 Identification of Herpesvirus Proteins that Contribute to G1/S Arrest. J. Virol. 88, 4480-4492.

Malik-Soni, N and Frappier, L 2014 Nucleophosmin Contributes to the Transcriptional Activation Function of the Epstein-Barr virus EBNA1 Protein. J. Virol. 88, 2323-2326.

Cao, JY, Shire, K, Landry,C, Gish, G, Pawson, T and Frappier, L. 2014 Identification of a Novel Protein Interaction Motif in the Regulatory Subunit of Protein Kinase CK2 used by Viral and Cellular Proteins. Mol. Cell. Biol., 34, 246-258.

Jagannathan, M., Nguyen, T., Gallo, D., Luthra, N., Brown, G. and Frappier, L. 2014 A Role for USP7 in DNA Replication. Mol. Cell. Biol. 34, 132-145.

Mansouri, S., Wang, S. and Frappier, L. 2013 A Role for the Nucleosome Assembly Proteins TAF-I beta and NAP1 in Activation of BZLF1 Expression and Epstein-Barr Virus Reactivation. PLoS ONE 8(5):e63802. PMID:23691099

Sarkari, F., Wheaton, K., La Delfa, A., Mohamed, M., Shaikh, F., Khatun, R., Arrowsmith, CH, Frappier, L., Saridakis, V. and Sheng, Y. 2013 USP7/HAUSP is a regulator of UbE2E1/UBCH6. J. Biol. Chem. 288(23), 16975-85. PMID: 23603909

Malik-Soni, N and Frappier, L 2012 Proteomic Profiling of EBNA1-Host Interaction in Latent and Lytic Epstein-Barr Virus Infections. J. Virol. 86, 6999-7002.

Nguyen, T., Jagannathan, M., and Frappier, L. 2012 Interactions of the human MCM-BP protein with MCM complex components and Dbf4. PLoS ONE. 7(4):e35931.

Sivachandran, N. Wang, X.. and Frappier, L. 2012 Functions of the Epstein-Barr Virus latency protein, EBNA1, in Viral reactivation and lytic infection. J.Virol. 86, 6146-58.

Jagannathan, M., Sakwe, A.M., Nguyen, T. and Frappier, L. 2012 The MCM-Associated Protein MCM-BP is Important for Human Nuclear Morphology. J. Cell Sci. 125, 133-143.

Salsman, J., M. Jagannathan, P. Paladino, P.-K. Chan, G. Dellaire, B. Raught, and L. Frappier. 2012 Proteomic Profiling of the Human Cytomegalovirus UL35 Gene Products Reveals a Role for UL35 in the DNA Repair Response. J. Virol. 86, 806-820. (cover for vol 86 issue 4)

Cao, J. Y., S. Mansouri, and L. Frappier. 2012 Changes in the nasopharyngeal carcinoma nuclear proteome induced by the EBNA1 protein of Eptein-Barr virus reveal potential roles for EBNA1 in metastasis and oxidative stress responses. J. Virol. 86, 382-394.

Sivachandran, N., Dawson, C.W., Young, L.S., Liu, F., Middeldorp, J. and Frappier, L. 2012 Contributions of the Epstein-Barr Virus EBNA1 Protein to Gastric Carcinoma. J. Virol. 86, 60-68.

Sivachandran, N., Thawe, N.N. and Frappier, L. 2011 Epstein-Barr Nuclear Antigen 1 Replication and Segregation Functions in Nasopharyngeal Carcinoma Cell Lines. J. Virol. 85, 10425-10430.

Salsman, J., Wang, X. and Frappier, L. 2011 Nuclear Body Formation and PML Body Remodeling by the Human Cytomegalovirus Protein UL35. Virology, 414, 119-129.

Welcker, M., Larimore, E.A., Frappier, L. and Clurman, B.E. 2011 Nucleolar Targeting of Fbw7 by EBNA1-Binding Protein 2 and Glycogen Synthase Kinase 3. Mol. Cell. Biol. 31(6):1214-24.

Sarkari, F, Wang, X., Nguyen, T and Frappier, L. 2011 The Herpesvirus Associated Ubiquitin Specific Protease, USP7, as a Negative Regulator of the PML Proteins and PML Nuclear Bodies. PLoS One, 6(1): e16598. doi:10.1371/journal.pone.0016598

Nishiyama, A., Frappier, L. and Mechali, M. 2011 MCM-BP Regulates Unloading of MCM2-7 Helicase in Late S Phase. Genes Dev. 25(2):165-75

Sarkari, F., Sheng, Y. and Frappier, L. 2010 USP7/HAUSP Promotes the Sequence-Specific DNA Binding Activity of p53. PLoS One. 5(9): e13040. doi:10.1371/journal.pone.0013040.

Sarkari, F., La Delfa, A., Arrowsmith, C.H., Frappier, L., Sheng, Y. and Saradakis, V. 2010 Further Insight into Substrate Recognition by USP7/HAUSP: Crystal Structures and Biochemical Analysis of the HdmX and Hdm 2 Interaction with USP7/HAUSP. J. Mol. Biol. 402, 825-837

Sivachandran, N., Cao, J.Y. and Frappier, L. 2010 Epstein-Barr Nuclear Antigen 1 Hijacks the Host Kinase CK2 to Disrupt PML Nuclear Bodies. J. Virol. 84(21) 11113-11123.

Nayyar, V., Shire, K and Frappier, L. 2009 Mitotic Chromosome Interactions of Epstein-Barr Nuclear Antigen 1 (EBNA1) and human EBNA1 binding protein 2 (EBP2). J. Cell Science. 122, 4341-4350.

Sarkari, F., Sanchez-Alcaraz, T., Wang, S., Holowaty, M.N., Sheng, Y. and Frappier, L. 2009 EBNA1-mediated Recruitment of a Histone H2B Deubiquitylating complex to the Epstein-Barr virus Latent Origin of DNA Replication. PLoS Pathogens, 5(10):e1000624.

Wang, S. and Frappier, L. 2009 Nucleosome Assembly Proteins Bind to Epstein-Barr Nuclear Antigen 1 (EBNA1) and Affect its Functions in DNA Replication and Transcriptional Activation. J. Virol. 83, 11704-11714.

Cochrane, A., Murley, L.L., Gao, M., Wong, R., Clayton, K., Brufatto, N., Canadien, V., Mamelak, D., Chen, T., Richards, D.,Zeghouf, M., Greenblatt, J., Burks, C. and Frappier, L. 2009 Stable complex formation between HIV Rev and the nucleosome assembly protein, NAP1, affects Rev function. Virology 388, 103-111.

Lin, A., Wang, S., Nguyen, T., Shire, K. and Frappier, L. 2008 Functional Interactions Between the EBNA1 Protein of Epstein-Barr Virus and Brd4. J. Virol. 82, 12009-12012.

Sivachandran, N., Sarkari, F. and Frappier, L. 2008 Epstein-Barr Nuclear Antigen 1 Contributes to Nasopharyngeal Carcinoma through disruption of PML Nuclear Bodies. PLoS Pathogens, 4(10): e1000170. doi:10.1371/journal.ppat.1000170.

Salsman, J., Zimmerman, N., Chen, T., Domagala, M. and Frappier, L. 2008 Genome-wide Screening of Herpes Simplex virus, Cytomegalovirus and Epstein-Barr virus Proteins for Subcellular Localization and Alteration of PML Nuclear Bodies. PLoS Pathogens 4(7): e1000100. doi:10.1371/journal.ppat.1000100

Freire, E., Oddo, C., Frappier, L. and de Prat-Gay, G. 2007. Kinetically driven refolding of the hyperstable EBNA1 origin DNA-binding dimeric b-barrel domain into amyloid-like spherical oligomers. PROTEINS: Structure, Function, and Bioinformatics, 70, 450-461.

Sakwe, A.M., Nguyen, T., Athanasopoulos, V., Shire, K. and Frappier, L. 2007. Identification and characterization of a novel component of the human MCM complex. Mol Cell Biol. 27, 3044-3055.

Oddo, C., Frappier, L. and de Prat Gay, G. 2006 Mechanism of DNA recognition at a viral replication origin. J. Biol. Chem. 281, 26893-26903.

Hegde, N.R., Chevalier, M.S., Wisner, T.W., Denton, M.C., Shire, K. Frappier, L. and Johnson, D.C. 2006. The role of Bip in ER-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins. J. Biol. Chem. 281, 20910-20919.

Shire,K., Kapoor, P., Jiang, K., Ng Thow Hing, M., Nguyen, T. and Frappier, L. 2006 Regulation of the EBNA1 Epstein-Barr virus protein by Serine Phosphorylation and Arginine Methylation. J. Virol. 80, 5261-5272.

Sheng, Y., Saridakis, V., Sarkari, F., Duan, S., Wu, T., Arrowsmith, C.H. and Frappier, L. 2006 Molecular recognition of p53 and Mdm2 by USP7/HAUSP. Nature Structural and Molecular Biology. 13, 285-291.

Gao, M., Brufatto, N., Chen, T., Murley, L.L., Thalakada, R., Domagala, M., Beattie, B., Mamelak, D., Athanasopoulos, V., Johnson, D., McFadden, G., Burks, C. and Frappier, L. 2005 Expression Profiling of Herpesvirus and Vaccinia Virus Proteins using a High-Throughput Baculovirus Screening System. J. Proteome Research 4, 2225-2235.

Kapoor, P., Lavoie, B. and Frappier, L. 2005 EBP2 plays a key role in Epstein-Barr Virus mitotic segregation and is regulated by Aurora family kinases. Mol. Cell Biol. 25, 4934-4945.

Saridakis, V., Sheng, Y., Sarkari, F., Holowaty, M.N., Shire, K., Nguyen, T., Zhang, R.G., Liao, J., Lee, W., Edwards, A.M., Arrowsmith, C.H. and Frappier, L. 2005 Structure of the p53-binding domain of HAUSP/USP7 bound to Epstein-Barr Nuclear Antigen 1: Implications for EBV-mediate immortalization. Mol. Cell 18, 25-36.

Holowaty, M.N., Sheng, Y., Nguyen, T., Arrowsmith, C. and Frappier, L. 2003. Protein interaction domains of the ubiquitin specific protease, USP7/HAUSP. J. Biol. Chem. 278, 47753-47761.

Avolio-Hunter, T.M. and Frappier, L. 2003. EBNA1 efficiently assembles on chromatin containing the Epstein-Barr virus origin of replication, oriP. Virology 315, 398-408.

Kapoor, P and Frappier, L. 2003. EBNA1 partitions Epstein-Barr virus plasmids in yeast by attaching to hEBP2 on mitotic chromosomes. J. Virol. 77, 6946-6956.

Holowaty, M.N., Zeghouf, M., Wu, H., Tellam, J., Athanasopoulos, V., Greenblatt, J. and Frappier, L. 2003. Protein profiling with Epstein-Barr nuclear antigen 1 reveals an interaction with the herpesvirus associated ubiquitin specific protease, HAUSP/USP7. J.Biol. Chem., 29987-29994.

Wu, H., Kapoor, P. and Frappier, L. 2002 Separation of the DNA replication, segregation and transcriptional activation functions of Epstein-Barr nuclear antigen 1. J. Virol. 25, 2480-2490.

Avolio-Hunter, T., Lewis, P.N. and Frappier, L. 2001. Epstein-Barr nuclear antigen 1 binds and destabilizes nucleosomes at the viral origin of latent DNA replication. Nucl. Acids Res. 29, 3520-3528.

Kapoor, P., Shire, K. and Frappier, L. 2001 Reconstitution of Epstein-Barr virus-based plasmid partitioning in budding yeast. EMBO J. 20, 222-230.

Mer, G., Bochkarev, A., Gupta, R., Bochkareva, E., Frappier, L., Ingles, C.J., Edwards, A.M. and Chazin, W.J. 2000 Structural basis for the recognition of DNA repair proteins UNG2, XPA and RAD52 by replication factor RPA. Cell, 103, 449-456.

Wu, H., Ceccarelli, D.F.J. and Frappier, L. 2000 The DNA segregation mechanism of the Epstein-Barr virus EBNA1 protein. EMBO Reports 1, 140-144.

Huber, M., Dworet, J.H., Shire, K., Frappier, L. and McAlear, M.A. 2000. The budding yeast homolog of the human EBNA1-binding protein 2 (Ebp2p) is an essential nucleolar protein required for pre-rRNA processing. J. Biol. Chem. 275, 28764-28773.

Cruickshank, J., Shire, K., Davidson, A., Edwards, A.M. and Frappier, L. 2000 Two domains of the Epstein-Barr virus origin DNA binding protein, EBNA1, orchestrate sequence-specific DNA binding. J. Biol. Chem. 275, 22273-22277.

Ceccarelli, D.F.J. and Frappier, L. 2000 Functional Analyses of the EBNA1 origin DNA binding protein of Epstein-Barr virus. J. Virol. 74; 4939-4948.

Bochkarev, A., Bochkareva, E., Frappier, L. and Edwards, A.M. 1999 The crystal structure of the complex of replication protein A subunits RPA32 and RPA14 reveals a mechanism for single-stranded DNA binding. EMBO J. 18, 4498-4504.

Shire, K., Ceccarelli, D.F., Avolio-Hunter, T.M. and Frappier, L. 1999 EBP2, a human protein that interacts with sequences of the Epstein-Barr nuclear antigen 1 important for plasmid maintenance. J. Virol. 73, 2587-2595.

Bochkarev, A, Bochkareva, E., Frappier, L. and Edwards, A.M. 1998 2.2 Å Structure of a permanganate-sensitive DNA site bound by the Epstein-Barr virus origin binding protein, EBNA1. J. Mol.. Biol. 284, 1273-1278.

Avolio-Hunter, T. and Frappier, L. 1998 Mechanistic studies on the DNA linking activity of the Epstein-Barr nuclear antigen 1. Nucl. Acids Res. 26, 4462-4470.

Bochkareva, E., Frappier, L., Edwards, A.M. and Bochkarev, A. 1998. The RPA32 subunit of human replication protein A contains a single-stranded DNA binding domain. J. Biol. Chem. 273, 3932-3936.

Zhang, D., Frappier, L., Gibbs, E., Hurwitz, J. and O'Donnell, M. 1998. Interaction of human RPA with EBNA1, the latent origin binding protein of Epstein-Barr virus. Nucl. Acid Res. 26, 631-637.

Blake, N., Lee, S., Redchenko, I., Thomas, W., Steven, N., Leese, A., Steigerwald-Mullen, P., Kurilla, M.G., Frappier, L. and Rickinson, A. 1997. Human CD8+ T cell responses to Epstein-Barr virus EBNA1: HLA class I presentation of the (Gly-Ala)- containing protein requires exogenous processing. Immunity 7, 791-802.

Summers, H., Flemming, A and Frappier, L. 1997. Requirements for EBNA1-induced permanganate sensitivity of the Epstein-Barr virus latent origin of DNA replication. J. Biol. Chem. 272, 26434-26440.

Bochkarev, A., Pfuetzner, R., Edwards, A. and Frappier, L. 1997. Crystal structure of the single-stranded DNA binding domain of replication protein A bound to DNA. Nature 385, 176-181.

Pfuetzner, R., Bochkarev, A., Frappier, L. and Edwards, A. 1997. Replication protein A: Characterization and crystallization of the DNA binding domain. J. Biol. Chem. 272, 430-434.

Ermakova, O.V., Frappier, L. and Schildkraut, C.L. 1996. Role of the EBNA1 protein in pausing of replication forks in the Epstein-Barr virus genome. J. Biol. Chem. 271, 33009- 33017.

Bochkarev, A., Barwell, J., Pfuetzner, R., Bochkareva, E., Frappier, L. and Edwards, A. (1996) Crystal structure of the DNA binding domain of the Epstein-Barr virus origin binding protein, EBNA1, bound to DNA. Cell 84, 791-800. Summers, H., Barwell, J., Pfuetzner, R., Edwards, A. and Frappier, L. (1996)

Cooperative assembly of EBNA1 on the Epstein-Barr virus latent origin of replication. J. Virol. 70, 1228-1231. Laine, A. and Frappier, L. (1995) Identification of a protein domain that can direct interactions at a distance between DNA binding proteins. J. Biol. Chem. 270, 30914-30918. Bochkarev, A., Barwell, J., Pfuetzner, R., Furey, W., Edwards, A. and Frappier, L. (1995)

Crystal structure of the DNA binding domain of the Epstein-Barr virus origin binding protein, EBNA1. Cell 83, 39-46. Barwell, J., Bochkarev, A., Pfuetzner, R., Tong, H., Yang, D., Frappier, L. and Edwards, A.M. (1995) Purification and crystallization of the DNA binding and dimerization domain of the Epstein-Barr virus nuclear antigen 1. J. Biol. Chem. 270, 20556-20559.

L. Frappier, K. Goldsmith and L. Bendell (1994) Stabilization of the EBNA1 protein on the Epstein-Barr virus latent origin of DNA replication by a DNA looping mechanism. J. Biol. Chem. 269, 1057-1062.

K. Goldsmith, L. Bendell and L. Frappier (1993) Identification of EBNA1 amino acid sequences required for the interaction of the functional elements of the Epstein-Barr virus latent origin of DNA replication. J. Virol. 67, 3418-3426.

Book Chapters and Reviews:

Frappier, L 2021 Epstein-Barr virus: Current Questions and Challenges. Tumour Virus Research, in press.

Cohan, B and Frappier, L 2021 Herpesvirus DNA Polymerase Processivity Factors: Not just for DNA Synthesis. Virus Research, 298:198394. doi:10.1016/j.virusres.2021.198394.

Frappier, L 2019 Epstein-Barr Virus: Overcoming the DNA Damage Response. Future Virology, 14(5).

Georges, A. and Frappier, L. 2017 Affinity Purification-Mass Spectroscopy Methods for Identifying Epstein-Barr virus-Host Interactions In Epstein-Barr Virus:Methods and Protocols. (J. Minarovits and H.H. Niller eds). Springer Press. Methods in Molecular Biology, 1532, 79-92.

Frappier, L. 2016 Manipulation of PML Nuclear Bodies and DNA Damage Responses by DNA Viruses. In The Functional Nucleus (D.J. Bazett-Jones and G. Dellaire eds). Springer International Publishing, 283-312.

Georges, A. and Frappier, L. 2015 Proteomics Methods for Discovering Viral-Host interactions. Methods 90, 21-17. PMID:25959231. doi: 10.1016/j.ymeth.2015.05.001

Frappier, L. 2015 EBNA1. In Epstein-Barr Virus Volume 2 (C. Munz ed). Current Topics in Microbiology and Immunology. 391, 3-34. PMID:26428370. doi 10.1007/978-3-319-22834-1_1

Frappier, L. 2015 Regulation of Herpesvirus Reactivation by Host miRNAs. J. Virol. 89, 2456-2458. PMID: 25540363

Frappier, L. 2015 Manipulation of PML Nuclear Bodies and DNA Damage Responses by DNA Viruses. In The Functional Nucleus (D. Bazett-Jones and G. Dellaire eds). Springer Press, submitted

Frappier, L. 2015 EBNA1. In Epstein-Barr Virus- One Herpes Virus, Many Diseases (C. Munz ed). Current Topics in Microbiology and Immunology. In press.

Frappier, L. 2013 A Cancer-associated Epstein-Barr Virus Variant with Epithelial Tropism. Trends in Microbiology, 21(12), 616-617.Frappier, L. 2013 EBNA1 and Epstein-Barr virus Associated Tumours. Springerbriefs in Cancer Research, vol 3, ISBN: 978-1-4614-6885-1.

Frappier, L. 2012 The Epstein-Barr Virus EBNA1 Protein. Scientifica, Vol 2012, Article ID 438204. doi:10.6064/2012/438204

Frappier, L. 2012 EBNA1 and Host Factors in Epstein-Barr Virus Latent DNA Replication. Current Opinion in Virology, 2,727-733.

Frappier, L. 2012 Contributions of Epstein-Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival. Viruses 4, 1537-1547.

Frappier, L. 2012 Role of EBNA1 in NPC Tumourigenesis. Seminars in Cancer Biology, 22, 154-161.

Frappier, L. 2012 PML Nuclear Body Disruption as a Treatment for Epstein-Barr Virus Associated Nasopharyngeal Carcinoma. Future Virology. 7(1), 1-3.

Frappier, L. and Verrijzer, C.P. 2011. Gene Expression Control by Protein Deubiquitinases. In Chromosomes and Expression Mechanisms. Current Opinions in Genetics and Development vol 21(2) (C.P. Verrijzer and A.Shilatifart ed.) 207-213.

Frappier, L. 2011 Viral Disruption of Promyelocytic Leukemia (PML) Nuclear Bodies by Hijacking Host PML Regulators. Virulence. 2(1):58-62.

Frappier, L. 2010. EBNA1 in Viral Replication and Persistence. In Epstein-Barr Virus: Latency and Transformation (E.S. Robertson ed.). Caister Academic Press, UK, ISBN: 978-1-904455-62-2.

Maxwell, K.L. and Frappier, L 2007 Viral Proteomics. Microbiology and Molecular Biology Reviews, 71(2), 71, 398-411.

Liu, F-F, Frappier, L, Kim, J., OSullivan, B., Hui, A., Bastianutto, C. 2006 East-West Symposium on Nasopharyngeal Cancer. International Journal of Radiation Oncology, Biology, Physics. 67, 703-708.

Holowaty, M.N. and Frappier, L. 2004 HAUSP/USP7 as an Epstein-Barr virus target. Biochemical Society Transactions 32, 731-732.

Kapoor, P. and Frappier, L. 2004. Methods for measuring the replication and segregation of Epstein-Barr Virus - based plasmids. In DNA Viruses: Methods and Protocols (P. Lieberman ed.). Humana Press Inc., 247-266.

Frappier, L. 2004. Viral plasmids in mammalian cells. In The Biology of Plasmids (B.E. Funnell and G.J. Phillips, eds.) ASM press, Washinton DC, 325-339.

Ceccarelli, D.F.J. and Frappier, L. 1999. Separation of the DNA replication and transactivation activities of EBNA1, the origin binding protein of Epstein-Barr virus. Gene Therapy and Molecular Biology. 3, 413-422.

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